Februar 2023 – MBExC

28.02.2023

In vitro reconstitution of chromatin domains

Authors Quililan K, Oberbeckmann E, Cramer P, Oudelaar AM Journal BioRxiv Citation bioRxiv 2023.02.27.530214. Abstract The spatial organization of the genome modulates nuclear processes, including transcription, replication, and DNA repair1,2. Eukaryotic genomes are organized into distinct 3D chromatin domains3. However, the molecular mechanisms that drive the formation

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28.02.2023

The multifaceted mitochondrial OXA insertase

Authors Homberg B, Rehling P, Cruz-Zaragoza LD Journal Trends in Cell Biology Citation Trends Cell Biol. 2023 Feb 28:S0962-8924(23)00020-X. Abstract Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are

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23.02.2023

ERC „Proof of Concept Grant“ für Tobias Moser

Prof. Dr. Tobias Moser, MBExC-Sprecher und Direktor des Instituts für Auditorische Neurowissenschaften an der Universitätsmedizin Göttingen, hat einen ERC „Proof of Concept Grant“ für sein Projekt zur „Erforschung wellenleiterbasierter Cochlea-Implantate für optogenetische Stimulation“ (OptoWave) erhalten. Die Förderung in Höhe von 150.000 Euro ermöglicht den Forschenden die Lücke zwischen den Entdeckungen

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23.02.2023

ERC Proof of Concept Grant für Tobias Moser

Hörforscher und Neurowissenschaftler der Universitätsmedizin Göttingen erhält Förderung des Europäischen Forschungsrats für das Projekt „Opto-Wave“ zur Optimierung des optischen Cochlea Implantats für die Anwendung bei Hörgeschädigten. (mbexc/umg) Prof. Dr. Tobias Moser, Direktor des Instituts für Auditorische Neurowissenschaften der Universitätsmedizin Göttingen (UMG), hat einen Proof of Concept Grant des Europäischen Forschungsrats

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22.02.2023

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism

Authors Grammatika Pavlidou N, Dobrev S, Beneke K, Reinhardt F, Pecha S, Jacquet E, Abu-Taha IH, Schmidt C, Voigt N, Kamler M, Schnabel RB, Baczkó I, Garnier A, Reichenspurner H, Nikolaev VO, Dobrev D, Molina CE Journal European Heart Journal Citation Eur Heart J. 2023 Feb 22:ehad086. Abstract Aims: Atrial

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22.02.2023

Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts

Authors Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Sakib MS, Burkhart S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2204933120. Abstract N6-methyladenosine (m6A) regulates mRNA

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17.02.2023

Molecular engineering to enhance reactivity and selectivity in an ultrafast photoclick reaction

Authors Fu Y, Simeth NA, Toyoda R, Brilmayer R, Szymanski W, Feringa BL Journal Angewandte Chemie International Edition Citation Angew Chem Int Ed Engl. 2023 Feb 17:e202218203. Abstract Light-induced 9,10-phenanthrenequinone-electron-rich alkene (PQ-ERA) photocycloadditions are an attractive new type of photoclick reaction, featuring fast conversions and high biocompatibility.

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15.02.2023

Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency

Authors Schlotawa L, Tyka K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregula J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J Journal EMBO Molecular Medicine Citation

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11.02.2023

Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls

Authors Senner F, Schneider-Axmann T, Kaurani L, Zimmermann J, Wiltfang J, von Hagen M, Vogl T, Spitzer C, Senner S, Schulte EC, Schmauß M, Schaupp SK, Reimer J, Reich-Erkelenz D, Papiol S, Kohshour MO, Lang FU, Konrad C, Kirchner SK, Kalman JL, Juckel G, Heilbronner M, Heilbronner U, Figge C,

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08.02.2023

NFATc1 is a central mediator of EGFR-induced ARID1A chromatin dissociation during acinar cell reprogramming

Authors Zhang Z, Wang X, Hamdan FH, Likhobabina A, Patil S, Aperdannier L, Sen M, Traub J, Neesse A, Fischer A, Papantonis A, Singh SK, Ellenrieder V, Johnsen SA, Hessmann E Journal Cellular and Molecular Gastroenterology and hepatology Citation Cell Mol Gastroenterol Hepatol. 2023 Feb 7:S2352-345X(23)00018-8. Abstract Background & aims:

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