2022

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03.10.2022

Seeded Binary Segmentation: A general methodology for fast andoptimal change point detection

Authors Kovács S, Li H, Bühlmann P, Munk A Journal Biometrika Citation Biometrika, 2022, asac052. Abstract We propose seeded binary segmentation for large scale changepoint detection problems. We construct a deterministic set of background intervals, called seeded intervals, in which single changepoint candidates are searched for. The final selection of
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01.10.2022

A Water-Soluble Manganese(II) Octanediaoate/Phenanthroline Complex Acts as an Antioxidant and Attenuates Alpha-Synuclein Toxicity

Authors DQueiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. Abstract
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27.09.2022

Die Sinne bewusst erleben

„Tag der Sinne“ am 8. Oktober 2022 im Forum Wissen Göttingen Hören, Sehen, Riechen, Schmecken und Tasten – mit unseren fünf Sinnen nehmen wir täglich unsere Umwelt wahr. Das Gezwitscher von Vögeln, den Geschmack unserer Lieblings-Eissorte oder die Schönheit eines Regenbogens erleben wir durch unsere Sinne. Gleichzeitig warnen sie uns
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Start of the new ECTU station at UMG

Start of the new ECTU station at UMG (from left): Prof. Dr. Frank Behrens (Division Head Clinical Studies at Fraunhofer ITMP), Prof. Dr. Martin Weber (Head ECTU at Fraunhofer ITMP, Translational Neuroinflammation and Automated Microscopy TNM), Prof. Dr. Stefan Jakobs (Site Manager Fraunhofer ITMP, Translational Neuroinflammation and Automated Microscopy TNM), Prof. Wolfgang Brück (UMG Board Speaker), Dr. Sabine Johannsen (State Secretary at MWK), Prof. Dr. Dr. Gerd Geißlinger (Head of Fraunhofer ITMP). Photo: umg/spförtner

23.09.2022

Neue Station für frühe klinische Studien (Early Clinical Trial Unit – ECTU)

Die Universitätsmedizin Göttingen (UMG) und das Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP eröffneten am Donnerstag, dem 15. September 2022, eine Early Clinical Trial Unit (ECTU) für frühe klinische Phase I-Studien. Der Schwerpunkt liegt dabei auf der erstmaligen klinischen Testung von Wirkstoffen zur Behandlung von weitgehend schwer therapierbaren (Autoimmun-)Erkrankungen des
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21.09.2022

Distribution of Distances based Object Matching: Asymptotic Inference

Authors Weitkamp CA, Proksch K, Tameling C, Munk A Journal Journal of the American Statistical Association Citation J Am Stat Assoc. 1-32. 2022. Abstract In this paper, we aim to provide a statistical theory for object matching based on a lower bound of the Gromov-Wasserstein distance related to the distribution
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20.09.2022

New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain

Authors Weninger G, Lehnart SE Journal Journal of Cellular Signaling Citation J Cell Signal. 2022;3(4):171-178. Abstract Junctophilin-2 (JP2) is a key structural protein of junctional membrane complexes (JMCs) that stabilize contacts between the sarcoplasmic reticulum and transverse tubules required for excitation-contraction (EC) coupling in cardiomyocytes. Under pathophysiological conditions, the intracellular
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15.09.2022

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

Authors Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N, Voigt N. Journal Communications Biology Citation Commun Biol 2022 Sep 15;5(1):969. Abstract Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer from low-throughput and require considerable experimenter expertise. Automated
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15.09.2022

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane

Authors Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F Journal Biomedicines Citation Biomedicines 2022, 10(9), 2294. Abstract The flavoprotein kynurenine 3-monooxygenase (KMO) is localised to the outer mitochondrial membrane and catalyses the synthesis of
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14.09.2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Authors Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2022 Sep 14;13(1):5385. Abstract Aggregation of amyloidogenic proteins is a characteristic of
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14.09.2022

Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case

Authors Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2022 Sep 14;23(18):10673. Abstract Skeletal Class III malocclusion with maxillary deficiency is a severe maxillofacial disease with unclear
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