2022

12.12.2022

Mono- and Intralink Filter (Mi-Filter) To Reduce False Identifications in Cross-Linking Mass Spectrometry Data

Authors Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F Journal Analytical Chemistry Citation Anal. Chem. 2022, 94, 51, 17751–17756. Abstract Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However,

Learn More

09.12.2022

Free-Breathing Liver Fat, R*2 and B0 Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-based Reconstruction

Authors Tan Z, Unterberg-Buchwald C, Blumenthal M, Scholand N, Schaten P, Holme C, Wang X, Raddatz D, Uecker M Journal IEEE Transactions on Medical Imaging Citation IEEE Trans Med Imaging. 2022 Dec 9;PP. Abstract This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition.

Learn More

08.12.2022

Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

Authors Galbusera R, Bahn E, Weigel M, Schaedelin S, Franz J, Lu PJ, Barakovic M, Melie-Garcia L, Dechent P, Lutti A, Sati P, Reich DS, Nair G, Brück W, Kappos L, Stadelmann C, Granziera C. Journal Brain Pathology Citation Brain Pathol. 2022 Dec 8:e13136. Abstract Quantitative MRI (qMRI) probes the

Learn More

07.12.2022

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in

Learn More

06.12.2022

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation

Authors Voigt N, Maack C, Pronto JRD Journal Journal of the American College of Cardiology Citation J Am Coll Cardiol. 2022 Dec, 80 (23) 2220–2223. Abstract No abstract available DOI 10.1016/j.jacc.2022.09.043 Pubmed Link

Learn More

01.12.2022

Filter-based models of suppression in retinal ganglion cells: comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal BioRxiv Citation bioRxiv 2022.12.01.518577. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of the neural activity. Computational models of the interplay of excitation and suppression in

Learn More

29.11.2022

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

Authors Pinheiro Neto J, Spitzner FP, Priesemann V Journal PLoS Computational Biology Citation PLoS Comput Biol 18(11): e1010678. Abstract To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity

Learn More

25.11.2022

Neuer SFB 1565 an der Universitätsmedizin Göttingen

Die Deutsche Forschungsgemeinschaft (DFG) fördert ab 1. Januar 2023 einen neuen Sonderforschungsbereich (SFB) unter Leitung der Universitätsmedizin Göttingen (UMG). Der neue SFB 1565 mit dem Titel „Molecular mechanisms and interplay of gene expression processes“/„Molekulare Mechanismen und Vernetzung von Prozessen der Genexpression“ erhält 10 Millionen Euro für eine erste Förderperiode von

Learn More

25.11.2022

Neues Mitglied im EMBO Young Investigator Programm

Als einer von 24 jungen Wissenschaftler*innen wird MBExC-Mitglied Prof. Dr. Hauke Hillen in das EMBO Young Investigator Programme aufgenommen. Das Programm unterstützt exzellente Gruppenleiter*innen, die seit weniger als vier Jahren in unabhängigen Positionen tätig sind und eine herausragende wissenschaftliche Erfolgsbilanz vorweisen können. Die neuen EMBO Young Investigators werden sich dem

Learn More

24.11.2022

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.

Learn More

Open Positions