2021

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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Synaptic diversity broadens the range of sound we can hear

Hearing occurs when sensory hair cells in the inner ear convert sound into neural signals transmitted to the brain. The sensory hair cells have about a dozen communication points with the auditory nerve fibers, called synapses. Scientists from the Institute for Auditory Neuroscience at the University Medical Center Göttingen discovered
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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Breites Klangspektrum dank synaptischer Vielfalt

Hören entsteht, wenn Sinneshaarzellen im Innenohr Schall in neuronale Signale umwandeln, die an das Gehirn weitergeleitet werden. Die Sinneshaarzellen haben etwa ein Dutzend Kommunikationspunkte mit den Hörnervenfasern, sogenannte Synapsen. Wissenschaftler des Instituts für Auditorische Neurowissenschaften an der Universitätsmedizin Göttingen entdeckten, dass die Synapsen einer einzelnen Sinneshaarzelle Schallinformationen unterschiedlich verarbeiten. Diese
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05.02.2021

Two mechanisms drive pronuclear migration in mouse zygotes

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei
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Dr. Alexander Dieter has been awarded the "Friedrich Hirzebruch Doctoral Prize for Mathematics, Natural and Engineering Sciences" 2021 by the German National Academic Foundation. Photo: private

05.02.2021

Promotionspreis der Studienstiftung für neurowissenschaftliche Hörforschung

Dr. Alexander Dieter, Nachwuchswissenschaftler in den Neurowissenschaften und Erstautor der MBExC-Publikation “μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve” (Sommer 2020 im EMBO Molecular Medicine Journal veröffentlicht), ist von der Studienstiftung des deutschen Volkes mit einem Promotionspreis  ausgezeichnet worden. Er erhielt den Preis für seine Doktorarbeit,
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04.02.2021

Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy

Authors Reinert MC, Pacheu-Grau D, Catarino CB, Klopstock T, Ohlenbusch A, Schittkowski M, Wilichowski E, Rehling P, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2021 Feb 4;16(1):64. Abstract Background: Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder and characterized by acute
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04.02.2021

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

Authors Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S. Journal Nature Communications Citation Nat Commun. 2021 Feb 4;12(1):782. Abstract The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins,
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04.02.2021

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.7 Å inside cells

Authors Tegunov D, Xue L, Dienemann C, Cramer P, Mahamid J Journal Nature Methods Citation Nat Methods 18, 186–193 (2021). Abstract Cryo-electron microscopy (cryo-EM) enables macromolecular structure determination in vitro and inside cells. In addition to aligning individual particles, accurate registration of sample motion and three-dimensional deformation during exposures are
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03.02.2021

Challenges facing quantitative large-scale optical super-resolution, and some simple solutions

Authors Dankovich TM, Rizzoli SO Journal iScience Citation iScience. 2021 Feb 3;24(3):102134. Abstract Optical super-resolution microscopy (SRM) has enabled biologists to visualize cellular structures with near-molecular resolution, giving unprecedented access to details about the amounts, sizes and spatial distributions of macromolecules in the cell. Precisely quantifying these molecular details requires
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Patrick Cramer © Irene Böttcher-Gajewski / MPI-BPC

02.02.2021

Patrick Cramer erhält Hector Wissenschaftspreis

Die Hector Stiftung ehrt den Direktor des Max-Planck-Instituts (MPI) für biophysikalische Chemie und Mitglied des MBExC, Prof. Dr. Patrick Cramer, für seine herausragende Forschung auf dem Gebiet der Gentranskription. Der Preis ist mit 150.000 Euro dotiert und wurde am 29. Januar im Rahmen einer virtuellen Veranstaltung verliehen. Link zur Pressemitteilung
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02.02.2021

Intranuclear immunostaining-based FACS protocol from embryonic cortical tissue

Authors Sakib MS, Sokpor G, Nguyen HP, Fischer A, Tuoc T Journal Star Protocols Citation STAR Protoc. 2021 Feb 2;2(1):100318. Abstract Cell sorting can be used to purify cell populations for cell type-specific molecular probing. Fluorescence-activated cell sorting (FACS) coupled with high-throughput sequencing affords molecular signature identification for specific cell
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