2021 – Seite 20

15.02.2021

Monitoring mitochondrial translation in living cells

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.

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12.02.2021

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Authors Brás IC, Outeiro TF Journal Cells Citation Cells 2021, 10(2), 375. Abstract The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis. The stereotypical distribution and evolution of the pathology during disease is often attributed to the cell-to-cell

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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life (Basel). 2021 Feb 11;11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of

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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life. 2021; 11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination

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11.02.2021

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming

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10.02.2021

The Coding And Small-Non-Coding Hippocampal Synaptic RNAome

Authors Epple R, Krüger D, Berulava T, Brehm G, Ninov M, Islam R, Köster S, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Feb 10. Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more

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10.02.2021

The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons

Authors Sertel SM, von Elling-Tammen MS, Rizzoli SO Journal Journal of Neuroscience Citation J Neurosci. 2021 Feb 10;41(6):1157-1173. Abstract The activity and the metabolism of the brain change rhythmically during the day/night cycle. Such rhythmicity is also observed in cultured neurons from the suprachiasmatic nucleus, which is a critical center

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09.02.2021

Erste klinische „Herzpflaster“-Studie weltweit

Erste Anwendung am Menschen: Die BioVAT-HF-DZHK20-Studie untersucht den Einsatz von aus Stammzellen gewonnenem Herzmuskelgewebe zur Behandlung von Patienten mit schwerer Herzinsuffizienz. Durch das Aufbringen von im Labor gezüchtetem Herzmuskelgewebe soll die Pumpfunktion von erkrankten Herzen nachhaltig verbessert werden. Die multizentrische klinische Studie wird mit der Rekrutierung von Patienten mit schwerer

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08.02.2021

Transcription activation depends on the length of the RNA polymerase II C-terminal domain

Authors Sawicka A, Villamil G, Lidschreiber M, Darzacq X, Dugast-Darzacq C, Schwalb B, Cramer P Journal EMBO Journal Citation EMBO J. 2021 Feb 8:e107015. Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail-like, intrinsically disordered carboxy-terminal domain (CTD) comprised of heptad-repeats, that functions in coordination of the transcription cycle

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08.02.2021

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling

Authors Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T Journal Development Citation Development. 2021 Feb 8;148(3):dev188276. Abstract Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels,

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