April

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30.04.2021

Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.
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29.04.2021

The Cdk8 kinase module regulates interaction of the Mediator complex with RNA polymerase II

Authors Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, Urlaub H, Cramer P Journal Journal of Biological Chemistry Citation J Biol Chem. 2021 Apr 29:100734. Abstract The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex Mediator, which regulates gene transcription by RNA
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3D microscopic image of an optical LED-based cochlear implant (blue LEDs in gray silicone encapsulation) with hair cells (orange) and auditory nerve (blue/green) in the cochlea of a common marmoset. Image: Daniel Keppeler, UMG

27.04.2021

Besser Hören mit optischen Cochlear-Implantaten

Bildgebende Verfahren ermöglichen entscheidenden Schritt zur Entwicklung neuartiger Hörprothesen Bei Cochlea-Implantaten beeinträchtigen Hintergrundgeräusche das Sprachverstehen. Die Teams von Tobias Moser und Tim Salditt (beide MBExC) konnten nun mit kombinierten bildgebenden Verfahren der Röntgentomographie und Fluoreszenzmikroskopie detaillierte Bilder der Cochlea von Nagetieren und nichtmenschlichen Primaten erstellen. Sie zeigen, dass eine räumlich
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3D microscopic image of an optical LED-based cochlear implant (blue LEDs in gray silicone encapsulation) with hair cells (orange) and auditory nerve (blue/green) in the cochlea of a common marmoset. Image: Daniel Keppeler, UMG

27.04.2021

Better hearing with optical cochlear implants

Understanding spoken words, developing normal speech – cochlear implants enable people with profound hearing impairment to gain a great deal in terms of quality of life. However, background noises are problematic, they significantly compromise the comprehension of speech of people with cochlear implants. The team led by Tobias Moser from
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26.04.2021

Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain

Authors Weish P, Lázaro DF, Palmares L, Santos PI, Stadelmann C, Höglinger GU, Rizzoli SO, Outeiro TF Journal bioRxiv Citation bioRxiv 2021.04.25.441304. Abstract Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson’s disease and other progressive neurodegenerative disorders known as Lewy body diseases (LBD). These proteinaceous deposits are immunopositive
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26.04.2021

Structure of human Mediator-RNA polymerase II pre-initiation complex

Authors Rengachari S, Schilbach S, Aibara S, Dienemann C, Cramer P Journal Nature Citation Nature 594, 129–133 (2021). Abstract Mediator is a conserved coactivator complex that enables the regulated initiation of transcription at eukaryotic genes1-3. Mediator is recruited by transcriptional activators and binds the pre-initiation complex (PIC) to stimulate the
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26.04.2021

Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

Authors Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R Journal Structure Citation Structure 2021 Apr 26:S0969-2126(21)00119-2 (in press). Abstract The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington’s
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22.04.2021

Multiple Haplotype Reconstruction from Allele Frequency Data

Authors Pelizzola M, Behr M, Li H, Munk A, Futschik A Journal Nature Computational Science Citation Nat Comput Sci 1, 262–271 (2021). Abstract Because haplotype information is of widespread interest in biomedical applications, effort has been put into their reconstruction. Here, we propose an efficient method, called haploSep, that is
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18.04.2021

Astrocytes control the spiking of mouse visual cortex layer 5 pyramidal neurons

Authors Sundaram SM, Garg P, Leßlich HM, Mathivanan S Journal Journal of Physiology Citation J Physiol. 2021 Jun;599(11):2793-2795. Abstract No abstract available. DOI 10.1113/JP2812364   Pubmed Link  
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14.04.2021

Cryo-electron tomography of native Drosophila tissues vitrified by plunge freezing

Authors Baeuerlein FJB, Pastor-Pareja JC, Fernandez-Busnadiego R Journal bioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to tissues, as they usually require high-pressure freezing for vitrification. Here we
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