Januar

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12.01.2021

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Authors Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P Journal Nature Communications Citation Nat Commun. 2021 Jan 12;12(1):279. Abstract Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as
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12.01.2021

Jörg Enderlein erhält ERC-Advanced Grant

Der Physiker und MBExC-Mitglied Prof. Dr. Jörg Enderlein von der Universität Göttingen hat einen Advanced Grant des Europäischen Forschungsrates (ERC) eingeworben. Der ERC fördert Enderleins Projekt mit dem Titel „Metallinduzierter Energietransfer einzelner Moleküle“ seit Anfang Januar 2021 fünf Jahre lang mit insgesamt rund 2,8 Millionen Euro. Mit Advanced Grants unterstützt
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Artificial cell membrane with fluorescent molecules (red spheres) over a graphene layer (hexagonal grid) as used for smMIET (Single-molecule, metal-induced energy transfer) measurements. Photo: Dr. Alexey Chizhik, University of Göttingen

12.01.2021

Jörg Enderlein receives ERC Advanced Grant

Physicist Professor and MBExC member Jörg Enderlein receives European Research Council Advanced Grant for his project „Single-molecule, metal-induced energy transfer“. (mbexc/pug) Physicist Professor Jörg Enderlein, PI of the Excellence Cluster „Multiscale Bioimaging“ (MBExC), from the University of Göttingen has been awarded an Advanced Grant by the European Research Council (ERC).
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11.01.2021

NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover

Authors Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO Journal BMC Molecular and Cell Biology Citation BMC Mol and Cell Biol 22, 5 (2021). Abstract Background Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these
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08.01.2021

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Authors Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2021 Jan 8;151:105256. Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)
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08.01.2021

Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions

Authors Zimmermann WH Journal Circulation Research Citation Circ Res. 2021 Jan 8;128(1):39-41. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.120.318494 Pubmed Link  
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07.01.2021

Understanding and treating paediatric hearing impairment

Authors Wrobel C, Zafeiriou MP, Moser T Journal EBioMedicine Citation EBioMedicine. 2021 Jan 7;63:103171. Abstract Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some
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07.01.2021

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

Authors Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Jan 7. Abstract In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies
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07.01.2021

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf
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05.01.2021

Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea

Authors Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H Journal Cell Reports Citation Cell Rep. 2021 Jan 5;34(1):108551. Abstract Recent studies reveal great diversity in the structure, function, and efferent innervation of afferent synaptic connections between the cochlear inner hair
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