2020

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06.05.2020

Light Microscopy of Mitochondria at the Nanoscale

Authors Jakobs S, Stephan T, Ilgen P, Brüser C Journal Annual Reviews of Biophysics Citation Annu Rev Biophys. 2020 May 6;49:289-308. Abstract Mitochondria are essential for eukaryotic life. These double-membrane organelles often form highly dynamic tubular networks interacting with many cellular structures. Their highly convoluted contiguous inner membrane compartmentalizes the
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05.05.2020

Testing for dependence on tree structures

Authors Behr M, Ansari MA, Munk A , Holmes C Journal Proceedings of the National Academy of Sciences of the United States of America Citation PNAS May 5, 2020 117 (18) 9787-9792. Abstract Tree structures, showing hierarchical relationships and the latent structures between samples, are ubiquitous in genomic and biomedical
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30.04.2020

Wide-Field Fluorescence Lifetime Imaging of Single Molecules

Authors Oleksiievets N, Thiele JC, Weber A, Gregor I, Nevskyi O, Isbaner S, Tsukanov R, Enderlein J Journal Journal of Physical Chemistry A Citation J Phys Chem A. 2020 Apr 30;124(17):3494-3500. Abstract Fluorescence lifetime imaging (FLIM) has become an important microscopy technique in bioimaging. The two most important of its applications are lifetime-multiplexing for imaging many different structures in
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24.04.2020

A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria

Authors Linden A, Deckers M, Parfentev I, Pflanz R, Homberg B, Neumann P, Ficner R, Rehling P, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2020 Apr 24;mcp.RA120.002028. Abstract Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only
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24.04.2020

Science und Society

Die Vermittlung wissenschaftlicher Erkenntnisse an die lokale, regionale, nationale und internationale Öffentlichkeit und deren Sensibilisierung für die integrative Forschung des MBExC ist für uns und für die Gesellschaft von großer Bedeutung. Hier treten wir in Dialog mit der Öffentlichkeit und fördern Interesse an der Wissenschaft und Vertrauen in die Forschung.
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22.04.2020

A Transcriptome Analysis Identifies Potential Preventive and Therapeutic Approaches Towards COVID-19

Authors Islam MR, Fischer A Journal Preprints Citation Preprints 2020, 2020040399. Abstract The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human health and the global economy. In addition to the development of vaccines there is an urgent need for preventive and therapeutic strategies towards severe
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22.04.2020

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‚Pioneer‘ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.
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15.04.2020

ERC Advanced Grant für Patrick Cramer

Jedes Jahr bewerben sich Spitzenforscher beim Europäischen Forschungsrat (ERC) um Fördermittel, besonders begehrt sind die hochdotierten ERC Advanced Grants. Der Göttinger Max-Planck-Direktor Patrick Cramer war dabei jetzt bereits zum dritten Mal erfolgreich – eine Ausnahmeleistung. Der Biochemiker erforscht, wie Zellen die im Erbgut gespeicherte Information nutzen. Seine Arbeit zur Regulation dieses
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08.04.2020

Challenges to heart repair with pluripotent stem cell-derived cardiomyocytes

Authors Zimmermann WH Journal Trends in Cardiovascular Medicine Citation Trends Cardiovasc Med 2020 Apr 8;S1050-1738(20)30049-9 Abstract no abstract available DOI 10.1016/j.tcm.2020.03.006 Pubmed Link  
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07.04.2020

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the
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