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23.08.2022

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species

Authors Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel
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22.08.2022

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
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18.08.2022

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming

Authors Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW Journal Star Protocols Citation STAR Protoc. 2022 Aug 18;3(3):101560. Abstract The methods for the culture and cardiomyocyte differentiation of human embryonic stem cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex and
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09.08.2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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07.08.2022

Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices

Authors Veress B, Peruzzi N, Eckermann M, Frohn J, Salditt T, Bech M, Ohlsson B Journal World Journal of Gastroenterology Citation World J Gastroenterol. Aug 7, 2022; 28(29): 3994-4006. Abstract Background: The enteric nervous system (ENS) is situated along the entire gastrointestinal tract and is divided into myenteric and submucosal
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03.08.2022

From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V Journal Biology Citation Biology (Basel). 2022 Aug 3;11(8):1164. Abstract Lead is a heavy metal whose widespread use has resulted in environmental contamination and significant health problems, particularly if the exposure occurs during developmental stages. It is a cumulative toxicant
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02.08.2022

Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice

Authors Dullin C, Svetlove A, Zschüntzsch J, Alves F Journal Scientific Reports Citation Sci Rep. 2022 Aug 2;12(1):13299. Abstract Retrospective gating (RG) is a well established technique in preclinical computed tomography (CT) to assess 3D morphology of the lung. In RG additional angular projections are recorded typically by performing multiple
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28.07.2022

Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study

Authors Lange T, Backhaus SJ, Beuthner BE, Topci R, Rigorth KR, Kowallick JT, Evertz R, Schnelle M, Ravassa S, Díez J, Toischer K, Seidler T, Puls M, Hasenfuß G, Schuster A Journal Journal of Cardiovascular Magnetic Resonance Citation J Cardiovasc Magn Reson. 2022 Jul 28;24(1):45. Abstract Background: Since cardiovascular magnetic
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23.07.2022

GGPS1-associated muscular dystrophy with and without hearing loss

Authors Kaiyrzhanov R, Perry L, Rocca C, Zaki MS, Hosny H, Araujo Martins Moreno C, Phadke R, Zaharieva I, Camelo Gontijo C, Beetz C, Pini V, Movahedinia M, Zanoteli E, DiTroia S, Vuillaumier-Barrot S, Isapof A, Mehrjardi MYV, Ghasemi N, Sarkozy A, Muntoni F, Whalen S, Vona B, Houlden H,
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21.07.2022

Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues

Authors Santos GL, DeGrave AN, Rehman A, Al Disi S, Xhaxho K, Schröder H, Bao G, Meyer T, Tiburcy M, Dworatzek E, Zimmermann WH, Lutz S Journal Biomaterials Advances Citation Biomater Adv. 2022 Jul 21:213041. Abstract Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs
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