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22.11.2024

Societal self-regulation induces complex infection dynamics and chaos

Authors Wagner J, Bauer S, Contreras S, Fleddermann L, Parlitz U, Priesemann V Journal Physical Review Research Citation Phys Rev Research. 2024. accepted paper. Abstract Classically, endemic infectious diseases are expected to display relatively stable, predictable infection dynamics. Accordingly, basic disease models such as the SIRS model display stable endemic
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20.11.2024

Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

Authors Cheng S, Schuh M Journal Nature Communications Citation Nat Commun. 2024 Nov 20;15(1):10044. Abstract In mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation
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20.11.2024

Nonlinear receptive fields evoke redundant retinal coding of natural scenes

Authors Karamanlis D, Khani MH, Schreyer HM, Zapp SJ, Mietsch M, Gollisch T Journal Nature Citation Nature. 2024 Nov 20. Abstract The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis1,2, which predicts that the retina reduces the redundancy inherent in natural scenes3
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15.11.2024

Trials and tribulations of cell therapy for heart failure: an update on ongoing trials

Authors Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasché P Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 Nov 15. Abstract Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with
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06.11.2024

α-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF

Authors da Silva IS, Cardoso AR, Reimer L, König A, van Riesen C, Outeiro TF, Jensen PH, Sales MGF Journal Biosensors and Bioelectronics Citation Biosensors and Bioelectronics 268 (2025) 116880. Abstract Aggregation of alpha-synuclein (aSyn) occurs in presynaptic neurons and constitutes a key factor for the progression of Parkinson’s disease,
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01.11.2024

A Unifying Approach to Distributional Limits for Empirical Optimal Transport

Authors Hundrieser S, Klatt M, Munk A, Staudt T Journal Bernoulli Citation Bernoulli 30 (4), 2846-2877. Abstract We provide a unifying approach to central limit type theorems for empirical optimal transport (OT). The limit distribution is given by a supremum of a centered Gaussian process, and we explicitly characterize when it
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30.10.2024

Identifiability of the Optimal Transport Cost on Finite Spaces

Authors Gonualez-Sanz A, Groppe M, Munk A Journal Arxiv Citation arXiv:2410.23146. Abstract The goal of optimal transport (OT) is to find optimal assignments or matchings between data sets which minimize the total cost for a given cost function. However, sometimes the cost function is unknown but we have access to
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30.10.2024

Stress Vulnerability Exposed by Mapping Brain Network States to Single-Cell Transcriptomes

Authors Fischer A, Radulovic J Journal Biological Psychiatry Citation Biol Psychiatry. 2024 Dec 1;96(11):832-834. Abstract No abstract available. DOI 10.1016/j.biopsych.2024.08.024   Pubmed Link
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27.10.2024

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal Journal of Chemical Information and Modeling Citation J Chem Inf Model. 2024 Oct 27. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a
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25.10.2024

Increased autonomous bioluminescence emission from mammalian cells by enhanced cofactor synthesis

Authors Brinker T, Gregor C Journal Chemosensors Citation Chemosensors 2024, 12, 223. Abstract The bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness. To improve light emission,
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