Research Alliance

Authors Reichardt M, Topperwien M, Khan A, Alves F, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Mar;7(2):023501. Abstract Purpose: We present a phase-contrast x-ray tomography study of wild type C57BL/6 mouse hearts as a nondestructive approach to the microanatomy on the scale of the

Authors Staudt T, Aspelmeier T, Laitenberger O, Geisler C, Egner A, Munk A Journal Statistical Science Citation Statist. Sci., Volume 35, Number 1 (2020), 92-111. Abstract Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units

Authors Vinçon B, Geisler C, Egner A Journal Optics Express Citation Opt. Express 28, 4516-4528 (2020). Abstract The achievable image quality in fluorescence microscopy and nanoscopy is usually limited by photobleaching. Reducing the light dose imposed on the sample is thus a challenge for all these imaging techniques. Various approaches

Authors Puls M, Beuthner BE, Topci R, Vogelgesang A, Bleckmann A, Sitte M, Lange T, Backhaus SJ, Schuster A, Seidler T, Kutschka I, Toischer K, Zeisberg EM, Jacobshagen C, Hasenfuß G Journal European Heart Journal Citation European Heart Journal, Volume 41, Issue 20, 21 May 2020, Pages 1903–1914. Abstract AIMS:

Authors Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y Journal Nature Citation Nature. 2020 Feb;578(7794):296-300. Abstract The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation

Authors Robisch AL, Eckermann M, Topperwien M, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham) 2020 Jan;7(1). Abstract X-ray cone-beam holotomography of unstained tissue from the human central nervous system reveals details down to subcellular length scales. This visualization of

Authors Töpperwien M, van der Meer F, Stadelmann-Nessler C, Salditt T Journal NeuroImage Citation Neuroimage 2020 Apr 15;210:116523. Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which is characterized by increasing dementia. It isaccompanied by the development of extracellularβ-amyloid plaques and neurofibrillary tangles in the gray matterof the brain. Histology

Authors Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P Journal EMBO Reports Citation EMBO Rep. 2020 Jan 7;21(1):e48833. Abstract The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric

Authors Eckermann M, Topperwien M, Robisch AL, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Apr 30;124(17):3482-3493. Abstract Purpose: Recently, progress has been achieved in implementing phase-contrast tomography of soft biological tissues at laboratory sources. This opens up opportunities

Authors Wang H, Farnung L, Dienemann C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020 Jan;27(1):8-13. Abstract Recognition of histone-modified nucleosomes by specific reader domains underlies the regulation of chromatin-associated processes. Whereas structural studies revealed how reader domains bind modified histone peptides, it is