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09.11.2020

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

Authors Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK Journal Elife Citation Elife. 2020 Nov 9;9:e62506. Abstract Insulin
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09.11.2020

X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular
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03.11.2020

Isolation of High Quality Murine Atrial and Ventricular Myocytes for Simultaneous Measurements of Ca2+ Transients and L-Type Calcium Current

Authors Tomsits P, Schüttler D, Kääb S, Clauss S, Voigt N Journal Journal of Visualized Experiments Citation J Vis Exp. 2020 Nov 3;(165). Abstract Mouse models play a crucial role in arrhythmia research and allow studying key mechanisms of arrhythmogenesis including altered ion channel function and calcium handling. For this
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01.11.2020

Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control

Authors Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H Journal Genetics Citation Genetics. 2020 Nov;216(3):735-752. Abstract Sleep is a conserved behavioral state. Invertebrates typically show quiet sleep, whereas in mammals, sleep consists of periods of nonrapid-eye-movement sleep (NREMS) and REM
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30.10.2020

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity.

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore
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30.10.2020

Defining the architecture of the human TIM22 complex by chemical crosslinking

Authors Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, Deckers M, Rehling P Journal FEBS Letters Citation FEBS Lett. 2020 Oct 30. Abstract The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The Translocase of the Inner
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28.10.2020

Connexin hemichannels in atrial fibrillation – Orphaned and irrelevant?

Authors Fakuade FE, Tomsits P, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2020 Oct 28:cvaa308. Abstract No abstract available DOI 10.1093/cvr/cvaa308 Pubmed Link  
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26.10.2020

Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation

Authors Sarkar A, Wang I, Enderlein J, Derouard J, Delon A Journal Optics Express Citation Opt Express. 2020 Oct 26;28(22):32936-32954. Abstract Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to image objects hidden behind visually opaque layers. Here, we show that a correlation analysis
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20.10.2020

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Authors Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu
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19.10.2020

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

Authors Wildemann B, Jarius S, Franz J, Ruprecht K, Reindl M, Stadelmann C Journal Acta Neuropathologica Citation Acta Neuropathol. 2020 Oct 19. Abstract no abstract available DOI 10.1007/s00401-020-02236-5 Pubmed Link  
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