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10.03.2025

Leaflet-specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers

Authors Karedla N, Schneider F, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Mar 10:e202423784. Abstract Polymer-supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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07.03.2025

Optimal and fast online change point estimation in linear regression

Authors Hüselitz A, Li H, Munk A Journal Arxiv Citation arXiv:2503.05270. Abstract We consider the problem of sequential estimation of a single change point in a piecewise linear regression model under a Gaussian setup. We demonstrate that a certain CUSUM-type statistic attains the minimax optimal rates for localizing the change
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06.03.2025

Structural basis of Nipah virus RNA synthesis

Authors Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Journal Nature Communications Citation Nat Commun. 2025 Mar 6;16(1):2261. Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its
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05.03.2025

A general framework for interpretable neural learning based on local information-theoretic goal functions

Authors Makkeh A, Graetz M, Schneider AC, Ehrlich DA, Priesemann V, Wibral M Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2408125122. Abstract Despite the impressive performance of biological and artificial networks, an intuitive
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04.03.2025

Adaptive monotonicity testing in sublinear time

Authors Li H, Liu Z, Munk A Journal Arxiv Citation arXiv:2503.03020. Abstract Modern large-scale data analysis increasingly faces the challenge of achieving computational efficiency as well as statistical accuracy, as classical statistically efficient methods often fall short in the first regard. In the context of testing monotonicity of a regression
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03.03.2025

A correlative workflow streamlines synaptic imaging by cryo-electron tomography

Authors Do TT, Siegert A, Domart F, Hahn F, Zeising C, Muth SM, Pape C, Kusch K, Dresbach T, Rizzoli S, Petrovic A, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2025.03.01.640558. Abstract Despite decades of intense research, the molecular organization of the synapse is not well understood. To address this issue,
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28.02.2025

Optimizing Electrical Field Stimulation Parameters Reveals the Maximum Contractile Function of Human Skeletal Muscle Microtissues

Authors Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Journal American Journal of Physiology. Cell Physiology Citation Am J Physiol Cell Physiol. 2025 Feb 28. Abstract Skeletal muscle microtissues are engineered to develop therapies for restoring
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27.02.2025

The keratin cortex stabilizes cells at high strains

Authors Meyer R, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Janshoff A, Köster S Journal BioRxiv Citation bioRxiv 2025.02.24.639846. Abstract The eukaryotic cytoskeleton consists of three filament types: actin filaments, microtubules and intermediate filaments (IFs). IF proteins are expressed in a cell-type specific manner, and keratins are found in
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26.02.2025

Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family

Authors Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, Koenig A, Birman S, Outeiro TF, Mansuy D, Dairou J   Journal ACS Chemical Neuroscience   Citation ACS Chem Neurosci. 2025 Feb 26.   Abstract The protein DJ-1 appears to play a protective role
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