Epigenetic Regulation of Gene Transcription

Authors Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 Jan 20:e11900. Abstract In current clinical practice, care

Authors Maier O, Baete SH, Fyrdahl A, Hammernik K, Harrevelt S, Kasper L, Karakuzu A, Loecher M, Patzig F, Tian Y, Wang K, Gallichan D, Uecker M, Knoll F Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2020 Nov 12. Abstract Purpose: The aim of this work is to

Authors Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H Journal Genetics Citation Genetics. 2020 Nov;216(3):735-752. Abstract Sleep is a conserved behavioral state. Invertebrates typically show quiet sleep, whereas in mammals, sleep consists of periods of nonrapid-eye-movement sleep (NREMS) and REM

Authors Wang X, Rosenzweig S, Scholand N, Holme HCM, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2020 Sep 16. Abstract Purpose: To develop a single-shot multi-slice T1 mapping method by combing simultaneous multi-slice (SMS) excitations, single-shot inversion-recovery (IR) radial fast low-angle shot (FLASH), and a nonlinear

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as

Authors Islam MR, Fischer A Journal Preprints Citation Preprints 2020, 2020040399. Abstract The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human health and the global economy. In addition to the development of vaccines there is an urgent need for preventive and therapeutic strategies towards severe

Authors Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y Journal Nature Citation Nature. 2020 Feb;578(7794):296-300. Abstract The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)

Authors Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K Journal European Journal of Heart Failure Citation Eur J Heart

Authors Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P Journal Cell Citation Cell. 2019 Dec 12;179(7):1525-1536.e12. Abstract Poxviruses use virus-encoded multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m(7)G-capped mRNAs in the host cytoplasm. In the accompanying paper, we report structures