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Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs

Authors Ghosh A, Sharma A, Chizhik AI, Isbaner S, Ruhlandt D, Tsukanov R, Gregor I, Karedla N, Enderlein J Journal Nature Photonics Citation Nat. Photonics 13, 860–865 (2019). Abstract Single-molecule fluorescence imaging has become an indispensable tool for almost all fields of research, from fundamental physics to the life sciences.

Authors Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF Journal Nature Protocols Citation Nat Protoc. 2019 Dec;14(12):3333-3365. Abstract Proteins are continually produced and degraded, to avoid the accumulation of old or damaged molecules and to maintain the efficiency of physiological processes. Despite its importance, protein turnover

Authors Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martinez-Sanchez A, Baumeister W, Stefan CJ, Fernandez-Busnadiego R Journal Developmental Cell Citation Developmental Cell 51, 476–487, November 18, 2019. Abstract Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) play fundamental roles

Authors Cramer P Journal Cell Citation Cell. 2019 Oct 31;179(4):808-812. Abstract This year we celebrate the 50th anniversary of the discovery of the three eukaryotic RNA polymerases. Ever since this seminal event in 1969, researchers have investigated the intricate mechanisms of gene transcription with great dedication. The transcription field continues

Authors Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin A, Chavent M, Chodera J, Condic-Jurkic K, Delemotte L, Grubmuller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A Journal Journal of Chemical Information

Authors Chen Y, Yong J, Martinez-Sanchez A, Yang Y, Wu Y, De Camilli P, Fernandez-Busnadiego R, Wu M Journal Journal of Cell Biology Citation J Cell Biol. 2019 Oct 7;218(10):3200-3211. Abstract Clathrin-mediated endocytosis depends on the formation of functional clathrin-coated pits that recruit cargos and mediate the uptake of those

Authors Moosa S, Yamamoto GL, Garbes L, Keupp K, Beleza-Meireles A, Moreno CA, Valadares ER, de Sousa SB, Maia S, Saraiva J, Honjo RS, Kim CA, Cabral de Menezes H, Lausch E, Lorini PV, Lamounier A Jr, Carniero TCB, Giunta C, Rohrbach M, Janner M, Semler O, Beleggia F, Li

Authors Töpperwien M, Markus A, Alves F, Salditt T Journal NeuroImage Citation Neuroimage. 2019;199:70-80. Abstract Knowledge of the three-dimensional (3d) neuronal cytoarchitecture is an important factor in order to understand the connection between tissue structure and function or to visualize pathological changes in neurodegenerative diseases or tumor development. The gold

Authors Cramer P Journal Nature Citation Nature. 2019 Sep;573(7772):45-54. Abstract The regulated transcription of genes determines cell identity and function. Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have revealed that transcription involves the condensation