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Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 3169-3180 (2021). Abstract High speed volumetric optical microscopy is an important tool for observing rapid processes in living cells or for real-time tracking of

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current

Authors Caizzi L, Monteiro-Martins S, Schwalb B, Lysakovskaia K, Schmitzova J, Sawicka A, Chen Y, Lidschreiber M, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 May 6;81(9):1920-1934.e9. Abstract Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly understood. Co-transcriptional splicing

Authors Banerjee S, Simonetti FL, Detrois KE, Kaphle A, Mitra R, Nagial R, Söding J Journal Genome Biology Citation Genome Biol. 2021 May 6;22(1):142. Abstract Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.

Authors Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, Urlaub H, Cramer P Journal Journal of Biological Chemistry Citation J Biol Chem. 2021 Apr 29:100734. Abstract The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex Mediator, which regulates gene transcription by RNA

Authors Weish P, Lázaro DF, Palmares L, Santos PI, Stadelmann C, Höglinger GU, Rizzoli SO, Outeiro TF Journal bioRxiv Citation bioRxiv 2021.04.25.441304. Abstract Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson’s disease and other progressive neurodegenerative disorders known as Lewy body diseases (LBD). These proteinaceous deposits are immunopositive

Authors Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R Journal Structure Citation Structure 2021 Apr 26:S0969-2126(21)00119-2 (in press). Abstract The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington’s