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Authors del Álamo M, Li H, Munk A Journal The Annals of Statistics Citation Ann. Statist. 49(3): 1318-1346 (June 2021). Abstract Despite the popularity and practical success of total variation (TV) regularization for function estimation, surprisingly little is known about its theoretical performance in a statistical setting. While TV regularization

Authors Klemp HG, Kettwig M, Streit F, Gärtner J, Rosewich H, Krätzner R Journal Metabolites Citation Metabolites. 2021 May 29;11(6):347. Abstract Peroxisomes are central hubs for cell metabolism and their dysfunction is linked to devastating human disorders, such as peroxisomal biogenesis disorders and single peroxisomal enzyme/protein deficiencies. For decades, biochemical

Authors Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P Journal Nature Communications Citation Nat Commun. 2021 May 28;12(1):3232. Abstract Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like

Authors Teiwes NK, Mey I, Baumann PC, Strieker L, Unkelbach U, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25805-25812. Abstract Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a

Authors Fianu I, Dienemann C, Aibara S, Schilbach S, Cramer P Journal Communications Biology Citation Commun Biol. 2021 May 21;4(1):606. Abstract Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with human

Authors Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E,

Authors Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A Journal Movement Disorders Citation Mov Disord. 2021 May 18. Abstract Background: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is

Authors Wang X, Tan Z, Scholand N, Roeloffs V, Uecker M Journal Philosophical Transactions Series A. Mathematical, physical, and engineering sciences Citation Philos Trans A Math Phys Eng Sci. 2021 Jun 28;379(2200):20200196. Abstract Conventional magnetic resonance imaging (MRI) is hampered by long scan times and only qualitative image contrasts that

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early