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24.04.2023

Quantitative Magnetic Resonance Imaging by Nonlinear Inversion of the Bloch Equations

Authors Scholand N, Wang X, Roeloffs V, Rosenzweig S, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2023 Apr 24. Abstract Purpose: Development of a generic model-based reconstruction framework for multiparametric quantitative MRI that can be used with data from different pulse sequences. Methods: Generic nonlinear model-based
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20.04.2023

Influence of phosphorylation on intermediate filaments

Authors Kraxner J, Köster S Journal Biological Chemistry Citation Biol Chem. 2023 Apr 20. Abstract The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety
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19.04.2023

Signatures of heterogeneity in the statistical structure of target state aligned ensembles

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.09719. Abstract Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that
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14.04.2023

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Authors Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann
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13.04.2023

A Bright Surprise: Live-Cell Labeling with Negatively Charged Fluorescent Probes based on Disulfonated Rhodamines and HaloTag

Authors Kim D, Stoldt S, Weber M, Jakobs S, Belov VN, Hell SW   Journal Chemistry Methods   Citation Chem. Methods 2023, e202200076.   Abstract Disulfonated rhodamines are photostable and bright dyes widely used in life science and optical microscopy. However, di-sulfonated dyes were considered cell impermeable and not applicable
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13.04.2023

3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis

Authors Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, Salditt T Journal Neuroscience Citation Neuroscience. 2023 Apr 13:S0306-4522(23)00161-6. Abstract We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze
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12.04.2023

Monitoring the response to Nintedanib treatment in a mouse model of lung fibrosis using longitudinal X-ray based lung function measurement

Authors Khan A, Markus AM, Svetlove A, Hülsmann S, Alves F, Dullin C Journal Research Square Citation Research Square, 12 April 2023, preprint. Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive, incurable, and debilitating fibrotic disease. Nintedanib – an oral tyrosine kinase inhibitor – significantly slows the IPF
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11.04.2023

Roadmap for Optical Tweezers

Authors Volpe G, Maragò OM, Rubinzstein-Dunlop H, Pesce G, Stilgoe AB, Volpe G, Tkachenko G, Truong VG, Chormaic SN, Kalantarifard F, Elahi P, Käll M, Callegari A, Marqués MI, Neves AAR, Moreira WL, Fontes A, Cesar CL, Saija R, Saidi A, Beck P, Eismann JS, Banzer P, Fernandes TFD, Pedaci
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11.04.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J   Journal BioRxiv   Citation bioRxiv 2023.04.11.535831.   Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer
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09.04.2023

Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F   Journal ArXiv   Citation arXiv:2304.04279.   Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse
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