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28.02.2025

Optimizing Electrical Field Stimulation Parameters Reveals the Maximum Contractile Function of Human Skeletal Muscle Microtissues

Authors Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Journal American Journal of Physiology. Cell Physiology Citation Am J Physiol Cell Physiol. 2025 Feb 28. Abstract Skeletal muscle microtissues are engineered to develop therapies for restoring
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27.02.2025

The keratin cortex stabilizes cells at high strains

Authors Meyer R, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Janshoff A, Köster S Journal BioRxiv Citation bioRxiv 2025.02.24.639846. Abstract The eukaryotic cytoskeleton consists of three filament types: actin filaments, microtubules and intermediate filaments (IFs). IF proteins are expressed in a cell-type specific manner, and keratins are found in
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26.02.2025

Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family

Authors Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, Koenig A, Birman S, Outeiro TF, Mansuy D, Dairou J   Journal ACS Chemical Neuroscience   Citation ACS Chem Neurosci. 2025 Feb 26.   Abstract The protein DJ-1 appears to play a protective role
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25.02.2025

The plastid-encoded RNA polymerase of plant chloroplasts

Authors Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T   Journal Trends in Plant Science   Citation Trends Plant Sci. 2025 Feb 25:S1360-1385(25)00031-7.   Abstract Plant chloroplasts possess a dedicated genome (plastome) and a prokaryotic-type plastid-encoded RNA polymerase (PEP) that mediates its expression. PEP is composed of five bacteria-like
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25.02.2025

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

Authors Flores-León M, Outeiro TF   Journal FEBS Journal   Citation FEBS J. 2025 Feb 25.   Abstract A possible consequence of the process of protein aggregation in neurodegenerative diseases is the depletion of soluble protein species (proteinopenia), which may, at least in some cases, reduce protein function/activity. This concept,
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23.02.2025

Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination

Authors Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A, Landt C, Rhee HJ, Rhee J, Gómez-Varela D, Schmidt M, Möbius W, Ruhwedel T, Pardo LA, Remling L, Kramann N, Wrzos C, Bahn E, Stadelmann C, Barrantes-Freer A Journal Journal of Neuroinflammation Citation J Neuroinflammation.
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14.02.2025

Molecular Level Super-Resolution Fluorescence Imaging

Authors Radmacher N, Chizhik AI, Nevskyi O, Gallea JI, Gregor I, Enderlein J Journal Annual Review of Biophysics Citation Annu Rev Biophys. 2025 Feb 14. Abstract Over the last 30 years, fluorescence microscopy, renowned for its sensitivity and specificity, has undergone a revolution in resolving ever-smaller details. This advancement began
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12.02.2025

Segment Anything for Microscopy

Authors Archit A, Freckmann L, Nair S, Khalid N, Hilt P, Rajashekar V, Freitag M, Teuber C, Buckley G, von Haaren S, Gupta S, Dengel A, Ahmed S, Pape C Journal Nature Methods Citation Nat Methods. 2025 Feb 12. Abstract Accurate segmentation of objects in microscopy images remains a bottleneck
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11.02.2025

Protein misfolding: understanding biology to classify and treat synucleinopathies

Authors Outeiro TF, Höglinger G, Lang AE, Vieira TCRG Journal Journal of Neural Transmission Citation J Neural Transm (Vienna). 2025 Feb 11. Abstract Protein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand
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06.02.2025

Guiding G protein signaling by target enhancement of GPCRs

Authors Mücher B, Garrido-Charles A, Cyganek L, Bruegmann T, Dalkara D, Siveke I, Herlitze S Journal BioRxiv Citation bioRxiv 2025.02.06.636923. Abstract Activation of G protein coupled receptors coupling to the Gi/o pathway leads to the activation of G protein-activated inward rectifier potassium channels (GIRK) in a fast membrane-delimited manner in
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