2024

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27.02.2024

Measuring sub-nanometer undulations at microsecond temporal resolution with metal- and graphene-induced energy transfer spectroscopy

Authors Chen T, Karedla N, Enderlein J Journal Nature Communications Citation Nat Commun. 2024 Feb 27;15(1):1789. Abstract Out-of-plane fluctuations, also known as stochastic displacements, of biological membranes play a crucial role in regulating many essential life processes within cells and organelles. Despite the availability of various methods for quantifying membrane
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21.02.2024

Machine learning and advanced statistical analysis for Fluorescence Correlation Spectroscopy

Authors Enderlein J Journal Biophysical Journal Citation Biophys J. 2024 Feb 21:S0006-3495(24)00131-0. Abstract No abstract available. DOI 10.1016/j.bpj.2024.02.011   Pubmed Link
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20.02.2024

Mouse oocytes sequester aggregated proteins in degradative super-organelles

Authors Zaffagnini G, Cheng S, Salzer MC, Pernaute B, Duran JM, Irimia M, Schuh M, Böke E  Journal Cell   Citation Cell. 2024 Feb 9:S0092-8674(24)00068-0.   Abstract Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm to support proper embryonic development. Protein aggregation is
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16.02.2024

A metabolically controlled contact site between vacuoles and lipid droplets in yeast

Authors Diep DTV, Collado J, Hugenroth M, Fausten RM, Percifull L, Wälte M, Schuberth C, Schmidt O, Fernández-Busnadiego R, Bohnert M   Journal Developmental Cell   Citation Dev Cell. 2024 Feb 16:S1534-5807(24)00036-4.   Abstract The lipid droplet (LD) organization proteins Ldo16 and Ldo45 affect multiple aspects of LD biology in
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16.02.2024

Near-optimal information relay by the neuronal population of layer 4 barrel cortex

Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal BioRxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the coordinated activities of populations of neurons, which, in turn, depend on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. In Layer 4 of
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16.02.2024

RNA helicase IGHMBP2 regulates THO complex to ensure cellular mRNA homeostasis

Authors Prusty AB, Hirmer A, Sierra-Delgado JA, Huber H, Guenther UP, Schlosser A, Dybkov O, Yildirim E, Urlaub H, Meyer KC, Jablonka S, Erhard F, Fischer U   Journal Cell Reports   Citation Cell Rep. 2024 Feb 16;43(2):113802.   Abstract RNA helicases constitute a large protein family implicated in cellular
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13.02.2024

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

Authors Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2024 Feb 13;15(1):1297. Abstract Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the
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09.02.2024

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction

Authors Gotthardt M, Lehnart SE   Journal Cardiovascular Research   Citation Cardiovasc Res. 2024 Feb 9:cvae030.   Abstract No abstract available.   DOI 10.1093/cvr/cvae030   Pubmed Link
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08.02.2024

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Authors Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S   Journal Nature Structural & Molecular Biology   Citation Nat Struct Mol Biol (2024).   Abstract Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system
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08.02.2024

Model-Based Reconstruction for Joint Estimation of T1, R∗2 and B0 Field Maps Using Single-Shot Inversion-Recovery Multi-Echo Radial FLASH

Authors Wang X, Scholand N, Tan Z, Mackner D, Telezki V, Blumenthal M, Schaten P, Uecker M Journal Arxiv Citation arXiv:2402.05366. Abstract Purpose: To develop a model-based nonlinear reconstruction for simultaneous water-specific T1, R∗2, B0 field and/or fat fraction (FF) mapping using single-shot inversion-recovery (IR) multi-echo radial FLASH. Methods: The
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