2021

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08.01.2021

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Authors Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2021 Jan 8;151:105256. Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)
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08.01.2021

Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions

Authors Zimmermann WH Journal Circulation Research Citation Circ Res. 2021 Jan 8;128(1):39-41. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.120.318494 Pubmed Link  
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07.01.2021

Understanding and treating paediatric hearing impairment

Authors Wrobel C, Zafeiriou MP, Moser T Journal EBioMedicine Citation EBioMedicine. 2021 Jan 7;63:103171. Abstract Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some
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07.01.2021

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

Authors Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Jan 7. Abstract In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies
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07.01.2021

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf
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05.01.2021

Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea

Authors Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H Journal Cell Reports Citation Cell Rep. 2021 Jan 5;34(1):108551. Abstract Recent studies reveal great diversity in the structure, function, and efferent innervation of afferent synaptic connections between the cochlear inner hair
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05.01.2021

Role of GTPases in Driving Mitoribosome Assembly

Authors Maiti P, Lavdovskaia E, Barrientos A, Richter-Dennerlein R Journal Trends in Cell Biology Citation Trends Cell Biol. 2021 Jan 5:S0962-8924(20)30254-3. Abstract Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant
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01.01.2021

JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: Mitochondrial protection and antioxidant properties

Authors Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y Journal Neurotoxicology Citation Neurotoxicology. 2021 Jan;82:89-98. Abstract We have previously shown that JM-20, a new chemical entity consisting of 1,5-benzodiazepine fused to a
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15.12.2020

Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei

Authors Wittmeier A, Cassini C, Töpperwien M, Denz M, Hagemann J, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Rad (2021) 28. Abstract X-rays are emerging as a complementary probe to visible-light photons and electrons for imaging biological cells. By exploiting their small wavelength
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