2020

Authors Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2020 Dec 9. Abstract Many different types of protein aggregates have attracted the minds and curiosity of countless armies of scientists, i.e., laboratories, in the world for more than 100 years. For example, it was in 1912 that F. Lewy

Authors Seefelder M, Alva V, Huang B, Engler T, Baumeister W, Guo Q, Fernández-Busnadiego R, Lupas AN, Kochanek S Journal BMC Evolutionary Biology Citation BMC Evol Biol. 2020 Dec 9;20(1):162. Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease

Authors Schnabel F, Kamphausen SB, Funke R, Kaulfuß S, Wollnik B, Zenker M Journal American Journal of Medical Genetics Part A Citation Am J Med Genet A. 2020 Dec 7. Abstract Cell division cycle 42 (CDC42) is a small Rho GTPase, which serves as a fundamental intracellular signal node regulating

Authors Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanovic D, Rizzoli S, Köster S Journal Scientific Reports Citation Sci Rep 10, 21086 (2020). Abstract Protein dynamics in the synaptic bouton are still not well understood, despite many quantitative studies of synaptic structure and function. The complexity of the synaptic

Authors Lavdovskaia E, Denks K, Nadler F, Steube E, Linden A, Urlaub H, Rodnina MV, Richter-Dennerlein R Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020 Dec 2;gkaa1132. Abstract Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure rapid and accurate synthesis of mitochondrial proteins. Defects in translation

Authors Bäuerlein FJB, Fernandez-Busnadiego R, Baumeister W Journal Trends in Cell Biology Citation Trends Cell Biol. 2020 Dec;30(12):951-966. Abstract Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still

Authors Mason FE, Pronto JRD, Alhussini K, Maack C, Voigt N Journal Basic Research in Cardiology Citation Basic Res Cardiol. 2020 Nov 30;115(6):72. Abstract The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific treatment options remain an unmet clinical need.

Authors Meinhardt J, Radke J, Dittmayer C, Mothes R, Franz J, Laue M, Schneider J, Brünink S, Hassan O, Stenzel W, Windgassen M, Rößler L, Goebel HH, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Heppner BI, Stadelmann

Authors Qin S, Isbaner S, Gregor I, Enderlein J Journal Nature Protocols Citation Nat Protoc. 2020 Nov 27. Abstract Fluorescence microscopy has become an indispensable tool for cell biology. Recently, super-resolution methods have been developed to overcome the diffraction limit of light and have shown living cells in unprecedented detail.

Authors Hehlert P, Zhang W, Göpfert MC Journal Trends in Neurosciences Citation Trends Neurosci. 2020 Nov 27:S0166-2236(20)30251-4. Abstract Mechanosensation in Drosophila relies on sensory neurons transducing mechanical stimuli into ionic currents. The molecular mechanisms of this transduction are in the process of being revealed. Transduction relies on mechanogated ion channels