2020

Authors Töpperwien M, van der Meer F, Stadelmann-Nessler C, Salditt T Journal NeuroImage Citation Neuroimage 2020 Apr 15;210:116523. Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which is characterized by increasing dementia. It isaccompanied by the development of extracellularβ-amyloid plaques and neurofibrillary tangles in the gray matterof the brain. Histology

Authors Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P Journal EMBO Reports Citation EMBO Rep. 2020 Jan 7;21(1):e48833. Abstract The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric

Authors Eckermann M, Topperwien M, Robisch AL, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Apr 30;124(17):3482-3493. Abstract Purpose: Recently, progress has been achieved in implementing phase-contrast tomography of soft biological tissues at laboratory sources. This opens up opportunities

Authors Wang H, Farnung L, Dienemann C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020 Jan;27(1):8-13. Abstract Recognition of histone-modified nucleosomes by specific reader domains underlies the regulation of chromatin-associated processes. Whereas structural studies revealed how reader domains bind modified histone peptides, it is

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)

Authors Töpperwien M, Markus A, Alves F, Salditt T Journal NeuroImage Citation Neuroimage. 2019;199:70-80. Abstract Knowledge of the three-dimensional (3d) neuronal cytoarchitecture is an important factor in order to understand the connection between tissue structure and function or to visualize pathological changes in neurodegenerative diseases or tumor development. The gold