2020

Authors Behr M, Ansari MA, Munk A , Holmes C Journal Proceedings of the National Academy of Sciences of the United States of America Citation PNAS May 5, 2020 117 (18) 9787-9792. Abstract Tree structures, showing hierarchical relationships and the latent structures between samples, are ubiquitous in genomic and biomedical

Authors Oleksiievets N, Thiele JC, Weber A, Gregor I, Nevskyi O, Isbaner S, Tsukanov R, Enderlein J Journal Journal of Physical Chemistry A Citation J Phys Chem A. 2020 Apr 30;124(17):3494-3500. Abstract Fluorescence lifetime imaging (FLIM) has become an important microscopy technique in bioimaging. The two most important of its applications are lifetime-multiplexing for imaging many different structures in

Authors Linden A, Deckers M, Parfentev I, Pflanz R, Homberg B, Neumann P, Ficner R, Rehling P, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2020 Apr 24;mcp.RA120.002028. Abstract Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only

Authors Islam MR, Fischer A Journal Preprints Citation Preprints 2020, 2020040399. Abstract The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human health and the global economy. In addition to the development of vaccines there is an urgent need for preventive and therapeutic strategies towards severe

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.

Authors Zimmermann WH Journal Trends in Cardiovascular Medicine Citation Trends Cardiovasc Med 2020 Apr 8;S1050-1738(20)30049-9 Abstract no abstract available DOI 10.1016/j.tcm.2020.03.006 Pubmed Link  

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the

Authors Satija R, Das A, Mühle S, Enderlein J, Makarov DE Journal Journal of Physical Chemistry B Citation J Phys Chem B. 2020 Apr 30;124(17):3482-3493. Abstract We study intrachain dynamics of intrinsically disordered proteins, as manifested by the time scales of loop formation, using atomistic simulations, experiment-parametrized coarse-grained models, and

Authors Zimmermann WH Journal Current Opinion in Physiology Citation Current Opinion in Physiology 2020, 14:70–77. Abstract The lack of regenerative therapies for the treatment of degenerative diseases, such as heart failure, motivates the search for cell therapeutics. From a technical point of view, cell-based heart repair is approached from two

Authors Ragamin A, Yigit G, Bousset K, Beleggia F, Verheijen FW, de Wit MCY, Strom TM, Dörk T, Wollnik B, Mancini GMS Journal American Journal of Medical Genetics Part A Citation Am J Med Genet A. 2020 Jun;182(6):1378-1386. Abstract DNA double-strand breaks (DSBs) are highly toxic DNA lesions that can