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29.06.2020

μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve

Authors Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2020 Jun 29;e12387. Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half
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22.06.2020

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

Authors Stephan T, Bruser C, Deckers M, Steyer M, Balzarotti F, Barbot M, Behr TS, Heim G, Hubner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S Journal EMBO Journal Citation EMBO J 2020 Jun 22;e104105
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22.06.2020

Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis

Authors Backhaus SJ, Lange T, Beuthner BE, Topci R, Wang X, Kowallick JT, Lotz J, Seidler T, Toischer K, Zeisberg EM, Puls M, Jacobshagen C, Uecker M, Hasenfuß G, Schuster A Journal Journal of Cardiovascular Magnetic Resonance Citation J Cardiovasc Magn Reson. 2020;22(1):46. Published 2020 Jun 22. Abstract Background: Myocardial
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16.06.2020

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

Authors Farnung L, Ochmann M, Cramer P Journal Elife Citation Elife. 2020;9:e56178. Published 2020 Jun 16. Abstract Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene
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16.06.2020

Large field-of-view scanning small-angle X-ray scattering of mammalian cells

Authors Cassini C, Wittmeier A, Brehm G, Denz M, Burghammer M, Köster S Journal Journal of Synchrotron Radiation Citation J. Synchrotron Rad. (2020). 27, 1059–1068. Abstract X-ray imaging is a complementary method to electron and fluorescence microscopy for studying biological cells. In particular, scanning small-angle X-ray scattering provides overview images of whole cells
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08.06.2020

Bi-allelic Missense Disease-Causing Variants in RPL3L Associate Neonatal Dilated Cardiomyopathy With Muscle-Specific Ribosome Biogenesis

Authors Ganapathi M, Argyriou L, Martínez-Azorín F,  Morlot S, Yigit G, Lee TM,  Auber B, von Gise A, Petrey DS, Thiele H, Cyganek L, Sabater-Molina M, Ahimaz P, Cabezas-Herrera J, Sorlí-García M, Zibat A, Siegelin MD, Burfeind P, Buchovecky CM, Hasenfuss G, Honig B, Li Y, Iglesias AD, Wollnik B Journal Human Genetics Citation Hum Genet. 2020 Jun 8. Online ahead of print. Abstract Dilated cardiomyopathy (DCM) belongs to the most frequent forms of cardiomyopathy mainly characterized by
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02.06.2020

The essential histogram

Authors Li H, Munk A, Sieling H, Walther G Journal Biometrika Citation Biometrika (2020), 107, 2, pp. 347–364 Abstract The histogram is widely used as a simple, exploratory way of displaying data, but it is usually not clear how to choose the number and size of the bins. We construct
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01.06.2020

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

Authors Drivas TG, Li D, Nair D, Alaimo JT, Alders M, Altmuller J, Barakat TS, Bebin EM, Bertsch NL, Blackburn PR, Blesson A, Bouman AM, Brockmann K, Brunelle P, Burmeister M, Cooper GM, Denecke J, … Wollnik B, et al. Journal European Journal of Human Genetics Citation Eur J Hum
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19.05.2020

19th Annual Meeting of the Safety Pharmacology Society: Regulatory and Safety Perspectives for Advanced Therapy Medicinal Products (Cellular and Gene Therapy Products)

Authors Cavero I, Seimetz D, Koziel D, Zimmermann WH, Holzgrefe HH Journal Expert Opinion Drug Safety Citation Expert Opin Drug Saf. 2020 May;19(5):553-558. Abstract This report summarizes and discusses talks delivered at an educational course offered during the 2019 Annual Meeting of the Safety Pharmacology Society on advanced therapy medicinal
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19.05.2020

Tomographic STED microscopy

Authors Krüger JR, Keller-Findeisen J, Geisler C, Egner A Journal Biomedical Optics Express Citation Biomed. Opt. Express 11, 3139-3163 (2020). Abstract Stimulated emission depletion (STED) microscopy is a versatile imaging method with diffraction-unlimited resolution. Here, we present a novel STED microscopy variant that achieves either increased resolution at equal laser
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