Urlaub, Henning

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31.12.2024

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

Authors Yousefi R, Cruz-Zaragoza LD, Valpadashi A, Hansohn C, Dahal D, Richter-Dennerlein R, Rizzoli S, Urlaub H, Rehling P, Pacheu-Grau D Journal Cell Reports Citation Cell Rep, 44, 115143. Abstract Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for
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24.10.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE Journal PLoS One Citation PLoS One. 2024 Oct 24;19(10):e0311203. Abstract Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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01.08.2024

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

Authors Amedei H, Paul NB, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation Front. Anal. Sci. 4:1425190. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de
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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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11.07.2024

A roadmap for ribosome assembly in human mitochondria

Authors Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2024 Jul 11. Abstract Mitochondria contain dedicated ribosomes
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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27.05.2024

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the
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