Simeth, Nadja

Authors Imse B, Rojas L, Herrero CG, Thallmair S, Rhee JS, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules is attractive to both study molecular

Authors Tovtik R, Marzin D, Weigel P, Crespi S, Simeth NA Journal Beilstein Journals of Organic Chemistry Citation Beilstein J Org Chem. 2025 Apr 25;21:830-838. Abstract Phenylazopyrazole photoswitches proved to be valuable structural motifs for various applications ranging from materials science to medicine. Despite their potential, their structural diversity is

Authors Cotroneo ER, Cheng TC, Kaltschnee L, Maibach P, Engelke M, Schwegler N, Thomas F, Thiele CM, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Peptides and proteins, that have the tendency to form aggregates, are often discussed in the context of Alz-heimer’s, Huntington’s, or Parkinson’s disease. However, studying aggregation

Authors Mougios N, Cotroneo ER, Imse N, Setzke J, Rizzoli S, Simeth NA, Tsukanov R, Opazo F Journal Nature Communications Citation Nat Commun. 2024 Oct 10;15(1):8771. Abstract Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, which have been

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling

Authors Chaudhuri A, Eijsink LE, Simeth NA Journal Chemical Communications (Cambridge) Citation Chem Commun (Camb). 2024 Aug 22. Abstract The dynamic regulation of pH via an external stimulus is an attractive technique to gate chemical transformations. Applying photons of different energy, we preferentially address either a photoacid or a photobase

Authors Fu Y, Simeth NA, Szymanski W, Feringa BL Journal Nature Reviews Chemistry Citation Nat Rev Chem. 2024 Aug 7. Abstract Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer

Authors Lāce I, Bazzi S, Uranga J, Schirmacher A, Diederichsen U, Mata RA, Simeth NA Journal ChemBioChem Citation Chembiochem. 2023 May 22:e202300270. Abstract Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus

Authors Fu Y, Simeth NA, Toyoda R, Brilmayer R, Szymanski W, Feringa BL   Journal Angewandte Chemie International Edition   Citation Angew Chem Int Ed Engl. 2023 Feb 17:e202218203.   Abstract Light-induced 9,10-phenanthrenequinone-electron-rich alkene (PQ-ERA) photocycloadditions are an attractive new type of photoclick reaction, featuring fast conversions and high biocompatibility.

Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in