Rizzoli, Silvio

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10.01.2023

Trafficking proteins show limited differences in mobility across different postsynaptic spines

Authors Mougios N, Opazo F, Rizzoli SO, Reshetniak S Journal iScience Citation iScience (2023). Abstract The function of the postsynaptic compartment is based on the presence and activity of postsynaptic receptors, whose dynamics are controlled by numerous scaffolding, signaling and trafficking proteins. While the receptors and the scaffolding proteins have
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09.08.2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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05.07.2022

An iodine-containing probe as a tool for molecular detection in secondary ion mass spectrometry

Authors Kabatas Glowacki S, Agüi-Gonzalez P, Sograte-Idrissi S, Jähne S, Opazo F, Phan NTN, Rizzoli SO Journal Chemical Communications Citation Chem. Commun., 2022,58, 7558-7561. Abstract We developed here an iodine-containing probe that can be used to identify the molecules of interest in secondary ion mass spectrometry (SIMS) by simple immunolabelling
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21.04.2022

A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry

Authors Li F, Fornasiero EF, Dankovich TM, Kluever V, Rizzoli SO Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2022, 23, 4615. Abstract Nano secondary ion mass spectrometry (nanoSIMS) imaging is a rapidly growing field in biological sciences, which enables investigators to describe the chemical composition of
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31.03.2022

Extracellular Matrix Recycling as a Novel Plasticity Mechanism With a Potential Role in Disease

Authors Dankovich TM, Rizzoli SO Journal Frontiers in Cellular Neuroscience Citation Front Cell Neurosci. 2022 Mar 31;16:854897. Abstract The extracellular matrix (ECM) stabilizes neural circuits and synapses in the healthy brain, while also retaining the ability to be remodeled, to allow synapses to be plastic. A well-described mechanism for ECM
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08.03.2022

The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic

Authors Dankovich TM, Rizzoli SO Journal Frontiers in Synaptic Neuroscience Citation Front Synaptic Neurosci. 2022 Mar 8;14:854956. Abstract In the adult brain, synapses are tightly enwrapped by lattices of the extracellular matrix that consist of extremely long-lived molecules. These lattices are deemed to stabilize synapses, restrict the reorganization of their
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04.03.2022

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Authors Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W Journal Nature Communications Citation Nat Commun. 2022 Mar 4;13(1):1163.  Abstract Myelin, the electrically insulating sheath on axons, undergoes dynamic
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08.12.2021

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Authors Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO Journal Nature Communications Citation Nat Commun. 2021 Dec 8;12(1):7129. Abstract The brain extracellular matrix (ECM) consists of
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11.10.2021

A microRNA signature that correlates with cognition and is a target against cognitive decline

Authors Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka
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30.08.2021

Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons

Authors Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO Journal Scientific Reports Citation Sci Rep. 2021 Aug 30;11(1):17374. Abstract A strong focus on sex-related differences has arisen recently in neurobiology, but most investigations focus on brain function in vivo, ignoring common experimental models like cultured neurons.
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