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06.09.2025

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Authors Holthusen H, Trinkaus VA, Fernandez Gonzalez C, Saha I, Pachmayr I, Wade OK, Dieser A, Hummel B, Yuste-Checa P, Ehses K, Körner R, Fernández-Busnadiego R, Sawarkar R, Jungmann R, Hipp MS, Hartl FU Journal BioRxiv Citation bioRxiv 2025.09.05.673478. Abstract Protein aggregation in various cellular compartments is a hallmark of
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05.09.2025

Uncoupling of CSF biomarkers and clinical status in patients with a novel mutation of ATP13a2

Authors Stephani C, Ewers D, Stausberg D, Rasche D, Bahiraee A, Ahmad B, Baehr M, Downie B, Hirschel S, Pauli SJ, Riedel C, Sachkova A, Salinas G, Schneider A, van Riesen C, Wollnik B, Yigit G, Nave K, Zerr I, Eggert S, Sereda MW Journal MedRxiv Citation medRxiv 2025.09.02.25334661. Abstract
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04.09.2025

A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson’s Disease

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Busnadiego RF, Mollenhauer B,
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03.09.2025

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Authors Siems SB, Jung RB, Jahn O, Meschkat M, Michanski S, Lukasik N, Hummert S, Sasmita AO, Mobius W, Benseler F, Brose N, Kramer-Albers EM, Haucke V, Nave KA, Werner HB Journal BioRxiv Citation bioRxiv 2025.09.02.673641. Abstract Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing
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02.09.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Kibédi CZ, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Science Advances Citation Science Advances, 2025. accepted manuscript. Abstract Our
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28.08.2025

Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins

Authors Pikunov AV, Syunyaev RA, Ali R, Prakosa A, Gams A, Boyle PM, Steckmeister V, Kutschka I, Rytkin E, Voigt N, Trayanova N, Efimov IR Journal Circulation: Arrhythmia and Electrophysiology Citation Circ Arrhythm Electrophysiol. 2025 Aug 28:e013898. Abstract Background: Atrial fibrillation (AF) is a progressive disease involving both structural and
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28.08.2025

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal Molecular Biology of the
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28.08.2025

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Authors Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU Journal Nature Communications Citation Nat Commun. 2025 Aug 28;16(1):8051. Abstract Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
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25.08.2025

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

Authors Sobitov I, Ritzenhoff K, Gaulrapp M, Becker L, Liutkute A, Seibertz F, Fakuade FE, Mason FE, Voigt N Journal The Journal of Physiology Citation J Physiol. 2025 Aug 25 Abstract Blebbistatin is an excitation-contraction uncoupling agent commonly used in cardiac optical mapping; however, it has been reported to influence
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22.08.2025

Online jump and kink detection in segmented linear regression: Statistical optimality meets computational efficiency

Authors Hüselitz A, Li H, Munk A Journal Arxiv Citation arXiv:2503.05270. Abstract We consider the problem of sequential (online) estimation of a single change point in a piecewise linear regression model under a Gaussian setup. We demonstrate that certain CUSUM-type statistics attain the minimax optimal rates for localizing the change
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