Outeiro, Tiago Fleming

Authors Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF Journal Chemistry – A European Journal Citation Chem. Eur. J.2023, e202300649. Abstract Alpha-Synuclein (α-Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleino-pathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V   Journal Cells   Citation Cells. 2023 Mar 6;12(5):818.   Abstract The nervous system is the primary target for lead exposure and the developing brain appears to be especially susceptible, namely the hippocampus. The mechanisms of lead neurotoxicity remain

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise

Authors Shvachiy L, Geraldes V, Outeiro TF Journal Antioxidants & Redox Signaling Citation Antioxidants & Redox Signaling. 2023. Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and ocuppational exposures to heavy metals are likely at

Authors Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2022;12(8):2397-2422. Abstract Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between

Authors DQueiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. Abstract

Authors Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F Journal Biomedicines Citation Biomedicines 2022, 10(9), 2294. Abstract The flavoprotein kynurenine 3-monooxygenase (KMO) is localised to the outer mitochondrial membrane and catalyses the synthesis of

Authors Brás IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF Journal Journal of Proteomics Citation J Proteomics. 2022 Sep 8:104721. Abstract Extracellular vesicles (EVs) are important mediators in intercellular communication. However, understanding the biological origin and functional effects of EVs

Authors Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V Journal Biology Citation Biology (Basel). 2022 Aug 3;11(8):1164. Abstract Lead is a heavy metal whose widespread use has resulted in environmental contamination and significant health problems, particularly if the exposure occurs during developmental stages. It is a cumulative toxicant