Outeiro, Tiago Fleming

Authors Flores-Leon M, Outeiro TF Journal Acta Neuropathologica Citation Acta Neuropathol. 2023 Jul 8. Abstract The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease (PD), and dementia with Lewy bodies (DLB). The main neuropathological hallmark of PD and

Authors Outeiro TF, Vieira TCRG Journal Nature Reviews. Neurology Citation Nat Rev Neurol. 2023 Jul 2. Abstract No abstract available. DOI 10.1038/s41582-023-00840-z   Pubmed Link  

Authors Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jun 28. Abstract The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to

Authors Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP Journal Chemical Reviews Citation Chem Rev. 2023 Jun 28. Abstract Biomolecular condensates, membrane-less entities arising from liquid-liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions,

Authors Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ Journal Movement Disorders Citation Mov Disord. 2023 May 8. Abstract Background: More than 200 years

Authors Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF Journal Chemistry – A European Journal Citation Chem. Eur. J.2023, e202300649. Abstract Alpha-Synuclein (α-Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleino-pathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of

Authors Shvachiy L, Geraldes V, Outeiro TF Journal Antioxidants & Redox Signaling Citation Antioxid. Redox Signal. 39, 321–335. Abstract Significance: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and occupational exposures to heavy metals are likely

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V   Journal Cells   Citation Cells. 2023 Mar 6;12(5):818.   Abstract The nervous system is the primary target for lead exposure and the developing brain appears to be especially susceptible, namely the hippocampus. The mechanisms of lead neurotoxicity remain

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise

Authors Shvachiy L, Geraldes V, Outeiro TF Journal Antioxidants & Redox Signaling Citation Antioxidants & Redox Signaling. 2023. Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and ocuppational exposures to heavy metals are likely at