Outeiro, Tiago Fleming

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent

Authors Folarin OR, Olopade FE, Gilbert TT, Ladagu AD, Pires Dos Santos PI, Mustapha OA, Kpasham LZ, Olopade JO, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2025 May;169(5):e70082. Abstract The interaction of toxic environmental metals and metalloids with brain proteins and polypeptides can result in pathological aggregations and

Authors Shvachiy L, Amaro-Leal A, Machado F, Rocha I, Geraldes V, Outeiro TF Journal Chemosphere Citation Chemosphere. 2025 May 9;380:144477. Abstract Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health concerns. Lead affects various body systems, especially the brain, causing long-lasting

Authors Abdelrasol H, Outeiro TF Journal Journal of the Society of Medical Sciences of Lisbon Citation JSCMed 2025;169(1). Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) as a result of intraneural deposition of aggregated alpha-synuclein

Authors Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, Koenig A, Birman S, Outeiro TF, Mansuy D, Dairou J   Journal ACS Chemical Neuroscience   Citation ACS Chem Neurosci. 2025 Feb 26.   Abstract The protein DJ-1 appears to play a protective role

Authors Flores-León M, Outeiro TF   Journal FEBS Journal   Citation FEBS J. 2025 Feb 25.   Abstract A possible consequence of the process of protein aggregation in neurodegenerative diseases is the depletion of soluble protein species (proteinopenia), which may, at least in some cases, reduce protein function/activity. This concept,

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, Ibáñez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Fernandez Busnadiego R,

Authors Outeiro TF, Höglinger G, Lang AE, Vieira TCRG Journal Journal of Neural Transmission Citation J Neural Transm (Vienna). 2025 Feb 11. Abstract Protein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand

Authors da Silva IS, Cardoso AR, Reimer L, König A, van Riesen C, Outeiro TF, Jensen PH, Sales MGF Journal Biosensors and Bioelectronics Citation Biosensors and Bioelectronics 268 (2025) 116880. Abstract Aggregation of alpha-synuclein (aSyn) occurs in presynaptic neurons and constitutes a key factor for the progression of Parkinson’s disease,

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal Journal of Chemical Information and Modeling Citation J Chem Inf Model. 2024 Oct 27. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a