Neher, Erwin

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24.10.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J. Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2305460120. Abstract Pre- and postsynaptic forms of long-term potentiation
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16.06.2023

Physiology of intracellular calcium buffering

Authors Eisner D, Neher E, Taschenberger H, Smith G Journal Physiological Reviews Citation Physiol Rev. 2023 Jun 16. Abstract Calcium signalling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is bound to buffers, with typically only about 1% being freely ionized at resting levels in most cells.
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11.04.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J   Journal BioRxiv   Citation bioRxiv 2023.04.11.535831.   Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer
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13.07.2022

A Sequential Two-Step Priming Scheme Reproduces Diversity in Synaptic Strength and Short-Term Plasticity

Authors Lin KH, Taschenberger H, Neher E Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207987119. Abstract Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional
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21.10.2021

Munc13-1 is a Ca 2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission

Authors Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N Journal Neuron Citation Neuron. 2021 Oct 21:S0896-6273(21)00727-3. Abstract During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to release
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15.03.2021

Non-negative Matrix Factorization as a Tool to Distinguish Between Synaptic Vesicles in Different Functional States

Authors Neher E, Taschenberger H Journal Neuroscience Citation Neuroscience. 2021 Mar 15;458:182-202. Abstract Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before being fusion competent. We present an analysis technique, which decomposes the time course of quantal release during repetitive stimulation as a sum of contributions of SVs,
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19.01.2021

Regulation of a subset of release-ready vesicles by the presynaptic protein Mover

Authors Pofantis E, Neher E, Dresbach T Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022551118. Abstract Neurotransmitter release occurs by regulated exocytosis from synaptic vesicles (SVs). Evolutionarily conserved proteins mediate the essential aspects of this process, including the membrane
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