Munk, Axel

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03.03.2021

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

Authors Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C, Llabrés S Journal Biochimica et Biophysica Acta – Biomembranes Citation Biochim Biophys Acta Biomembr. 2021 Mar 3:183601. Abstract Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross the
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27.01.2021

Multiscale quantile segmentation

Authors Vanegas LJ, Behr M, Munk A Journal Journal of the American Statistical Association Citation Journal of the American Statistical Association. 2021 Jan 27. Abstract We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does
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13.11.2020

Variational Multiscale Nonparametric Regression: Algorithms and Implementation

Authors del Alamo M, Li H, Munk A, Werner F Journal Algorithms Citation Algorithms 2020, 13(11), 296. Abstract Many modern statistically efficient methods come with tremendous computational challenges, often leading to large-scale optimisation problems. In this work, we examine such computational issues for recently developed estimation methods in nonparametric regression
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14.10.2020

Heterogeneous Idealization of Ion Channel Recordings — Open Channel Noise

Authors Pein F, Bartsch A, Steinem C, Munk A Journal IEEE Transactions on Nanobioscience Citation IEEE Trans Nanobioscience. 2020 Oct 14;PP. Abstract We propose a new model-free segmentation method for idealizing ion channel recordings. This method is designed to deal with heterogeneity of measurement errors. This in particular applies to
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02.06.2020

Empirical regularized optimal transport: Statistical theory and applications

Authors Klatt M, Tameling C, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 2 (2), 419-443. Abstract We derive limit distributions for various empirical regularized optimal transport quantities between probability distributions supported on a finite metric space and show their
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02.06.2020

The essential histogram

Authors Li H, Munk A, Sieling H, Walther G Journal Biometrika Citation Biometrika (2020), 107, 2, pp. 347–364 Abstract The histogram is widely used as a simple, exploratory way of displaying data, but it is usually not clear how to choose the number and size of the bins. We construct
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05.05.2020

Testing for dependence on tree structures

Authors Behr M, Ansari MA, Munk A , Holmes C Journal Proceedings of the National Academy of Sciences of the United States of America Citation PNAS May 5, 2020 117 (18) 9787-9792. Abstract Tree structures, showing hierarchical relationships and the latent structures between samples, are ubiquitous in genomic and biomedical
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03.03.2020

Statistical Molecule Counting in Super-Resolution Fluorescence Microscopy: Towards Quantitative Nanoscopy

Authors Staudt T, Aspelmeier T, Laitenberger O, Geisler C, Egner A, Munk A Journal Statistical Science Citation Statist. Sci., Volume 35, Number 1 (2020), 92-111. Abstract Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units
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22.07.2019

Molecular contribution function in RESOLFT nanoscopy

Authors Frahm L, Keller-Findeisen J, Alt P, Schnorrenberg S, Del Alamo Ruiz M, Aspelmeier T, Munk A, Jakobs S, Hell SW Journal Optics Express Citation Opt Express. 2019 Jul 22;27(15):21956-21987. Abstract BACKGROUND: The ultimate objective of a microscope of the highest resolution is to map the molecules of interest in
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04.02.2019

High-resolution experimental and computational electrophysiology reveals weak beta-lactam binding events in the porin PorB

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs
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