Moser, Tobias

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand

Authors Khurana L, Harczos T, Moser T, Jablonski L Journal iScience Citation iScience (2023). Abstract In 2019, disabling hearing loss affected 430 million people worldwide and will reach over 700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by electrical cochlear implants (eCIs) bypassing dysfunctional or lost hair

Authors Michanski S, Kapoor R, Steyer A, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, Moser T, Wichmann C Journal Embo Reports Citation EMBO Reports (2023)e56702. Abstract Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly

Authors Zerche M, Wrobel C, Kusch K, Moser T, Mager T Journal Molecular Therapy: Methods and Clinical Development Citation Molecular Therapy: Methods & Clinical Development Vol. 29 June 2023. Abstract Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically

Authors Hunniford V, Kühler R, Wolf B, Keppeler D, Strenzke N, Moser T Journal Frontiers in Neuroscience Citation Front Neurosci. 2023 Jan 23;17:1105562. Abstract Background The electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency

Authors Mittring A, Moser T, Huet AT Journal Brain Stimulation Citation Brain Stimul. 2023 Jan 23:S1935-861X(23)01673-X. Abstract Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)

Authors Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D Journal Materials (Basel) Citation Materials (Basel). 2022 Dec 22;16(1):106. Abstract Improved hearing restoration by cochlear implants (CI) is expected

Authors Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM Journal Developmental Dynamics Citation Dev Dyn. 2022 Oct 25. Abstract Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure