Moser, Tobias

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03.06.2024

Catching up but still miles behind — a patient registry for otoferlin

Authors Vona B, Wollnik B, Strenzke N, Moser T Journal Experimental & Molecular Medicine Citation Exp Mol Med (2024). Abstract No abstract available. DOI 10.1038/s12276-024-01247-6   Pubmed Link
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09.04.2024

Toward Optogenetic Hearing Restoration

Authors Huet A, Mager T, Goßler C, Moser T Journal Annual Review of Neurosciences Citation Annu Rev Neurosci. 2024 Apr 9. Abstract The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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28.02.2024

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Authors Hain PJH, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 17:1351280. Abstract Introduction: Recently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic function independent of electrophysiological
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19.12.2023

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell

Authors Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2023 Dec 19:100704. Abstract In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory
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12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
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08.12.2023

Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Authors Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T Journal Protein & Cell Citation Protein & Cell. 2023 Dec 8:pwad058. accepted manuscript.
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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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06.10.2023

Diversity matters – extending sound intensity coding by inner hair cells via heterogeneous synapses

Authors Moser T, Karagulyan N, Neef J, Jaime Tobon LM Journal EMBO Journal Citation EMBO J. 2023.e114587. Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal
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22.09.2023

Devising a framework of optogenetic coding in the auditory pathway: insights from auditory midbrain recordings

Authors Micheal M, Wolf BJ, Klinge-Strahl A, Jeschke M, Moser T, Dieter A Journal Brain Stimulation Citation Brain Stimul. 2023 Sep 29:S1935-861X(23)01920-4. Abstract Cochlear implants (CIs) restore activity in the deafened auditory system via electrical stimulation of the auditory nerve. As the spread of electric current in biological tissues is
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