Möbius, Wiebke

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10.01.2024

Folate receptor α deficiency – Myelin-sensitive MRI as a reliable biomarker to monitor the efficacy and long-term outcome of a new therapeutic approach

Authors Dreha-Kulaczewski S, Sahoo P, Preusse M, Gkalimani I, Dechent P, Helms G, Hofer S, Steinfeld R, Gärtner J Journal Journal of Inherited Metabolic Disease Citation J Inherit Metab Dis. 2024 Mar;47(2):387-403. Abstract Cerebral folate transport deficiency, caused by a genetic defect in folate receptor α, is a devastating neurometabolic
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08.12.2023

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

Authors Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C Journal iScience Citation iScience. 2023 Dec 8;27(1):108700. Abstract Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand
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10.08.2023

Age-dependent structural reorganization of utricular ribbon synapses

Authors Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C Journal Frontiers in Cell and Developmental Biology Citation Front. Cell Dev. Biol., 10 August 2023. Abstract In mammals,
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06.07.2023

Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing

Authors Michanski S, Kapoor R, Steyer A, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, Moser T, Wichmann C Journal Embo Reports Citation EMBO Reports (2023)e56702. Abstract Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly
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29.06.2023

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Authors Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich
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06.04.2023

C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: A multi-cohort proteomics and immuno-assay validation study

Authors Chatterjee M, Özdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, Pham TV, Chiasserini D, Piersma SR, Knol JC, Möbius W, Mollenhauer B, van der Flier WM, Jimenez CR, Teunissen CE, Jahn O, Schneider A Journal Alzheimer’s & Dementia: The Journal of the Alzheimers Association Citation Alzheimers Dement.
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03.04.2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Authors Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D’Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M,
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16.12.2022

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Authors Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2022;12(8):2397-2422. Abstract Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between
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10.11.2022

Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag

Authors Steyer AM, Buscham TJ, Lorenz C, Hümmert S, Eichel-Vogel MA, Schadt LC, Edgar JM, Köster S, Möbius W, Nave KA, Werner HB Journal Glia Citation Glia. 2022 Nov 10. Abstract Healthy myelin sheaths consist of multiple compacted membrane layers closely encasing the underlying axon. The ultrastructure of CNS myelin
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21.10.2022

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

Authors Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M Journal Science Citation Oct 21;378(6617):eabq4835. Abstract Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for
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