Lehnart, Stephan

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22.04.2024

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

Authors Amedei H, Paul N, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation bioRxiv 2024.04.22.590599. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein/protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de novo detection
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21.03.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Sillje HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE   Journal BioRxiv   Citation bioRxiv 2024.03.21.586093.   Abstract Background: Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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19.03.2024

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Schwenzer N, Dresbach T, Lehnart S, Moser T Journal BioRxiv Citation bioRxiv 2024.03.18.585517. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ
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10.03.2024

3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes

Authors Pochechueva TV, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, Lehnart SE Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2024 Mar 10;25(6):3183. Abstract We present novel workflows for Q-FISH nanoscopy with the potential for prognostic applications and resolving novel chromatin compaction changes. DNA-fluorescence
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28.02.2024

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Authors Schwenzer N, Tsukanov R, Kohl T, Basak S, Seibertz F, Voigt N, Enderlein J, Lehnart SE   Journal BioRxiv   Citation bioRxiv 2024.02.26.582084.   Abstract The clustering of L-type calcium channels in cardiac myocytes presents an important mechanism for functional regulation of calcium signaling. Here we applied targeted super-resolution
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09.02.2024

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction

Authors Gotthardt M, Lehnart SE   Journal Cardiovascular Research   Citation Cardiovasc Res. 2024 Feb 9:cvae030.   Abstract No abstract available.   DOI 10.1093/cvr/cvae030   Pubmed Link
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05.01.2024

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM

Authors Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jan 5. Abstract Patient-derived induced pluripotent stem cells (iPSC) can be differentiated into atrial and ventricular cardiomyocytes to allow for
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06.10.2023

Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

Authors Tolstik E, Lehnart SE, Soeller C, Lorenz K, Sacconi L Journal Trends in Biotechnology Citation Trends Biotechnol. 2023 Oct 6:S0167-7799(23)00241-X. Abstract Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive understanding of the heart and its functions at various levels, from the molecular to the
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30.06.2023

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

Authors Baeuerlein FJB, Renner M, El Chami D, Lehnart SE, Pastor-Pareja JC, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to voluminous biological specimens such
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14.06.2023

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes

Authors Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A Journal Circulation Research Citation Circ Res. 2023 Jun 14.
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