Lehnart, Stephan

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16.10.2025

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Authors Schwenzer N, Tsukanov R, Kohl T, Basak S, Sobitov I, Seibertz F, Kapoor R, Voigt N, Enderlein J, Lehnart SE   Journal Journal of Molecular and Cellular Cardiology Plus   Citation J Mol Cell Cardiol Plus. 14 (2025) 100490.   Abstract The clustering of L-type calcium channels (LTCC) for
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15.10.2025

Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation

Authors Pronto JRD, Mason FE, Rog-Zielinska EA, Fakuade FE, Bülow D, Tóth M, Machwart K, Brandes P, Wiedmann F, Kohlhaas M, Nickel A, Wolf M, Mustroph J, Vu KC, Brandenburg S, Do TQ, Siedler PJ, Ritzenhoff K, Xue Z, Zhou X, Kestel S, Dschun O, Kyshynska O, Kensah G, Rebbeck
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07.10.2025

A versatile microfluidics platform for enhanced multi-target super-resolution microscopy

Authors Basak S, Chi-Vu K, Mougios N, Oleksiievets N, Pollack Y, Brandenburg S, Opazo F, Lehnart SE, Enderlein J, Tsukanov R Journal BioRxiv Citation bioRxiv 2025.10.07.680900. Abstract DNA-based Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is a powerful variant of single-molecule localization microscopy (SMLM) that overcomes the limitations of
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30.05.2025

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Authors Habeck M, Saleem N, Plota D, Cheruiyot C, Kohl T, Lehnart S, Jakobs S, Ebert A Journal BioRxiv Citation bioRxiv 2025.05.28.655290. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess
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24.10.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE Journal PLoS One Citation PLoS One. 2024 Oct 24;19(10):e0311203. Abstract Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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01.08.2024

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

Authors Amedei H, Paul NB, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation Front. Anal. Sci. 4:1425190. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de
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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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02.07.2024

Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction

Authors Lahiri SK, Lu J, Aguilar-Sanchez Y, Li H, Moreira LM, Hulsurkar MM, Mendoza A, Turkieltaub Paredes MR, Navarro-Garcia JA, Munivez E, Horist B, Moore OM, Weninger G, Brandenburg S, Lenz C, Lehnart SE, Sayeed R, Krasopoulos G, Srivastava V, Zhang L, Karch JM, Reilly S, Wehrens XHT Journal Journal
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25.06.2024

Structural insights into the regulation of RyR1 by S100A1

Authors Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024
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24.06.2024

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

Authors Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack
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