Bock, Lars

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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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19.03.2024

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Authors Morici M, Gabrielli S, Fujiwara K, Paternoga H, Beckert B, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2432.   Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to
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