Janshoff, Andreas

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27.02.2025

The keratin cortex stabilizes cells at high strains

Authors Meyer R, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Janshoff A, Köster S Journal BioRxiv Citation bioRxiv 2025.02.24.639846. Abstract The eukaryotic cytoskeleton consists of three filament types: actin filaments, microtubules and intermediate filaments (IFs). IF proteins are expressed in a cell-type specific manner, and keratins are found in
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24.04.2024

Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy

Authors Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A Journal Biological Chemistry Citation Biol Chem. 2024 Apr 24. Abstract Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here,
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry Citation Chemistry. 2023 Jul 11;29(39):e202203904. Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of them is E-cadherin which
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of
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14.06.2023

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes

Authors Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A Journal Circulation Research Citation Circ Res. 2023 Jun 14.
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08.03.2023

Bioinspired Membrane Interfaces: Controlling Actomyosin Architecture and Contractility

Authors Liebe NL, Mey I, Vuong L, Shikho F, Geil B, Janshoff A, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11586-11598. Abstract The creation of biologically inspired artificial lipid bilayers on planar supports provides a unique platform to study membrane-confined processes in
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10.10.2022

From LUVs to GUVs – how to cover micrometer-sized pores with membranes

Authors Kramer K, Sari M, Schulze K, Flegel H, Stehr M, Mey I, Janshoff A, Steinem C Journal Journal of Physical Chemistry B Citation J. Phys. Chem. B 2022, 126, 41, 8233–8244. Abstract Pore-spanning membranes (PSMs) are a versatile tool to investigate membrane-confined processes in a bottom-up approach. Pore sizes
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04.01.2022

Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin‑1 -PI(4,5)P2 Interaction in Constrained Geometries

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force
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