Jahn, Reinhard

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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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27.12.2023

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses

Authors Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos
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19.12.2023

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell

Authors Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2023 Dec 19:100704. Abstract In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory
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26.10.2023

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

Authors Binotti B, Ninov M, Cepeda AP, Ganzella M, Matti U, Riedel D, Urlaub H, Sambandan S, Jahn R Journal Autophagy Citation Autophagy. 2023 Oct 26:1-19. Abstract In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane
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23.11.2022

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.
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08.03.2022

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Authors Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S Journal Neuron Citation Neuron. 2022 Mar 4:S0896-6273(22)00146-5. Abstract Vesicular transporters (VTs) define the
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04.01.2022

Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin‑1 -PI(4,5)P2 Interaction in Constrained Geometries

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force
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11.02.2021

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming
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12.01.2021

Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels

Authors Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G Journal Cell Reports Citation Cell Rep. 2021 Jan 12;34(2):108623. Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear.
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