Grubmüller, Helmut

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07.08.2023

Structural conservation of antibiotic interaction with ribosomes

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are
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31.03.2023

Effects of cryo-EM cooling on structural ensembles

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what
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27.03.2023

Discrimination between cyclic-nucleotides by cyclic-nucleotide gated ion channels

Authors Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S   Journal Nature Structural and Molecular Biology   Citation Nat Struct Mol Biol. 2023 Mar 27.   Abstract Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the
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21.01.2023

Simulation of Complex Biomolecular Systems: The Ribosome Challenge

Authors Bock LV, Gabrielli S, Kolá MH, Grubmüller H   Journal Annual Review of Biophysics   Citation Annu. Rev. Biophys. 2023. 52:15.1–15.30.   Abstract Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied
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28.02.2022

Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact
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22.07.2021

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Authors Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN Journal Nature Communications Citation Nat Commun 12, 4466 (2021). Abstract Macrolides and ketolides comprise a family of clinically important antibiotics that
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28.10.2019

Sharing Data from Molecular Simulations

Authors Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin A, Chavent M, Chodera J, Condic-Jurkic K, Delemotte L, Grubmuller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A Journal Journal of Chemical Information
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