Grubmüller, Helmut

Authors Otteson L, Nagy G, Kunkel J, Kodis G, Zheng W, Bignon C, Longhi S, Grubmüller H, Vaiana AC, Vaiana SM Journal BioRxiv Citation bioRxiv 2024.07.22.604679. Abstract The RNA genome of measles virus is encapsidated by the nucleoprotein within a helical nucleocapsid that serves as template for both transcription and

Authors Lauer SM, Reepmeyer M, Berendes O, Klepacki D, Gasse J, Gabrielli S, Grubmüller H, Bock LV, Krizsan A, Nikolay R, Spahn CMT, Hoffmann R Journal Nature Communications Citation Nat Commun 15, 3945 (2024). Abstract Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis by binding to the polypeptide exit tunnel

Authors Bock LV, Igaev M, Grubmüller H Journal Current Opinion in Structural Biology Citation Curr Opin Struct Biol. 2024 May 8;86:102825. Abstract Knowledge of the structure and dynamics of biomolecules is key to understanding the mechanisms underlying their biological functions. Single-particle cryo-electron microscopy (cryo-EM) is a powerful structural biology technique

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what

Authors Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S   Journal Nature Structural and Molecular Biology   Citation Nat Struct Mol Biol. 2023 Mar 27.   Abstract Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the

Authors Bock LV, Gabrielli S, Kolá MH, Grubmüller H   Journal Annual Review of Biophysics   Citation Annu. Rev. Biophys. 2023. 52:15.1–15.30.   Abstract Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact

Authors Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN Journal Nature Communications Citation Nat Commun 12, 4466 (2021). Abstract Macrolides and ketolides comprise a family of clinically important antibiotics that

Authors Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin A, Chavent M, Chodera J, Condic-Jurkic K, Delemotte L, Grubmuller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A Journal Journal of Chemical Information