Griesinger, Christian

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13.12.2019

The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.
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01.08.2019

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau

Authors Brendel M, Deussing M, Blume T, Kaiser L, Probst F, Overhoff F, Peters F, von Ungern-Sternberg B, Ryazanov S, Leonov A, Griesinger C, Zwergal A, Levin J, Bartenstein P, Yakushev I, Cumming, P, Boening G, Ziegler S, Herms J, Giese A, Rominger A Journal Alzheimers’s Research and Therapy Citation
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31.05.2019

Depopulation of dense alpha-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

Authors Wegrzynowicz, M.Bar-On D, Calo L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, Ashery U, Spillantini MG Journal Acta Neuropathologica Citation Acta Neuropathol. 2019 Oct;138(4):575-595. Abstract Parkinson’s disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies
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05.02.2018

Anle138b modulates alpha-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

Authors Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N Journal Movement Disorders Citation Mov Disord. 2019 Feb;34(2):255-263. Abstract BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of alpha-synuclein
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