Griesinger, Christian

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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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10.10.2024

Direct optical measuerement of intramolecular distances with angstrom precision

Authors Sahl SJ, Matthias J, Inamdar K, Weber M, Khan TA, Brüser C, Jakobs S, Becker S, Griesinger C, Broichhagen J, Hell SW Journal Science Citation Science. 2024 Oct 11;386(6718):180-187. Abstract Optical investigations of nanometer distances between proteins, their subunits, or other biomolecules have been the exclusive prerogative of Förster
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27.08.2024

The amyloid oligomer modulator anle138b has disease modifying effects in a human IAPP transgenic mouse model of type 2 diabetes mellitus (hIAPP Ob/Ob mice)

Authors Albariqi MMA, Baauw SMG, Fens SPJP, Versteeg S, Ryazanov S, Leonov A, Willemen HLDM, Stathonikos N, Seychell RM, El Saghir A, Gerritsen B, Khemtemourian L, Vassallo N, Giese A, Eijkelkamp N, Griesinger C, Höppener JWM Journal BioRxiv Citation bioRxiv 2024.08.27.609850. Abstract Cytotoxic aggregates of human islet amyloid polypeptide (hIAPP)
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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20.03.2024

[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brain

Authors Saw RS, Buss S, Schmidt F, Ryazanov S, Leonov A, Kuebler L, Bleher D, Papadopoulos I, Roeben B, Schmidt F, Reimold M, Bonanno F, Grotegerd AK, Ruf V, Dahl B, Sandiego C, Henry K, Fehrenbacher B, Schaller M, Kahle P, Gasser T, Brockmann K, Reischl G, la Fougère C,
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13.02.2024

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

Authors Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2024 Feb 13;15(1):1297. Abstract Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the
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08.04.2023

Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR

Authors Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, Leonov A, Carlos Fuentes-Monteverde J, Wegstroth M, Giller K, Mathies G, Giese A, Becker S, Griesinger C, Andreas LB Journal Methods Citation Methods. 2023 Apr 8:S1046-2023(23)00056-7. Abstract Small molecules that bind to oligomeric protein species such as
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10.11.2022

The 3D structure of lipidic fibrils of α-synuclein

Authors Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB, Becker S, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2022 Nov 10;13(1):6810. Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-synucleinopathies, such as Parkinson’s disease,
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14.09.2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Authors Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2022 Sep 14;13(1):5385. Abstract Aggregation of amyloidogenic proteins is a characteristic of
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09.09.2022

Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1

Authors Karschin N, Becker S, Griesinger C Journal Journal of the American Chemical Society Citation J Am Chem Soc. 2022 Sep 9. Abstract Paramagnetic NMR constraints are very useful to study protein interdomain motion, but their interpretation is not always straightforward. On the example of the particularly flexible complex Calmodulin/Munc13-1,
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