de Groot, Bert

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01.06.2025

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Authors Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schroeder G, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.05.30.655790. Abstract Alzheimer’s disease is a specific neurodegenerative
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22.04.2025

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils

Authors Kim M, Matthes D, Frieg B, Leonov A, Ryazanov S, Bleher D,Grotegerd AK, Dienemann C, Giese A, Schröder GF, Becker S, Herfert K, de Groot BL, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.04.21.649837. Abstract Accumulation of α-synuclein (αSyn) aggregates in the human brain is the major hallmark
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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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06.01.2025

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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06.01.2025

NOMPC ion channel hinge forms a gating-spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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14.09.2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Authors Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2022 Sep 14;13(1):5385. Abstract Aggregation of amyloidogenic proteins is a characteristic of
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