Cramer, Patrick

Authors Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH Journal Molecular Cell Citation Mol Cell. 2020 Dec 23:S1097-2765(20)30906-0. Abstract Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator

Authors Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG Journal Nature

Authors Osman S, Cramer P Journal Annual Review of Cell and Developmental Biology Citation Annu Rev Cell Dev Biol. 2020 Oct 6;36:1-34. Abstract Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the eukaryotic genome and a focal point for cellular regulation during

Authors Cramer P Journal Cell Citation Cell. 2020 Aug 20;182(4):787-789. Abstract Rosalind Franklin provided the key data for deriving the double helix structure of DNA. The English chemist also pioneered structural studies of colloids, viruses, and RNA. To celebrate the 100th anniversary of Franklin’s birth, I summarize her work, which

Authors Farnung L, Ochmann M, Cramer P Journal Elife Citation Elife. 2020;9:e56178. Published 2020 Jun 16. Abstract Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene

Authors Vos SM, Farnung L, Linden A, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020. Abstract Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We previously reported an activated porcine Pol II elongation complex, EC*, encompassing

Authors Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesús M, Mendieta-Esteban J, Tian TV, Choi J, Berenguer C, Abad A, Borsari B, le Dily F, Cramer P, Marti-Renom MA, Stadhouders R, Graf T Journal Nature Genetics Citation Nat Genet. 2020 Jul;52(7):655-661. Abstract Three-dimensional organization of the genome is important

Authors Parfentev I, Schilbach S, Cramer P, Urlaub H Journal Journal of Proteomics Citation J Proteomics. 2020 May 30;220:103754. Abstract Cross-linking mass spectrometry (XL-MS) is steadily expanding its range of applications from purified protein complexes to more complex samples like organelles and even entire cells. One main challenge using non-cleavable

Authors Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P Journal Nature Citation Nature 584, 154–156 (2020). Abstract The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes1-3. Here

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.