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17.09.2025

Optimal Transport Based Testing in Factorial Design

Authors Groppe M, Niemöller L, Hundrieser S, Ventzke D, Blob A, Köster S, Munk A Journal Arxiv Citation arXiv:2509.13970. Abstract We introduce a general framework for testing statistical hypotheses for probability measures supported on finite spaces, which is based on optimal transport (OT). These tests are inspired by the analysis
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17.09.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal Science Advances Citation Science Advances. 2025. accepted manuscript. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with
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15.09.2025

Manipulating mitochondrial gene expression

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in
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11.09.2025

Charge-Dependent Fluorescence Lifetime Modulation in a Plasmonic Nanocavity

Authors Chizhik AI, Sakhapov DI, Gregor I, Karedla N, Enderlein J Journal The journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2025 Sep 11:9900-9905. Abstract Electric charges play a fundamental role in shaping the structure, function, and interactions of biomolecules, yet precisely measuring these charges at the single-molecule
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11.09.2025

Visual objects refine head direction coding

Authors Siegenthaler D, Denny H, Carrasco SS, Mayer JL, Levenstein D, Peyrache A, Trenholm S, Macé E Journal Science Citation Science. 2025 Sep 11;389(6765):eadu9828. Abstract Animals use visual objects to guide navigation-related behaviors. However, visual object-preferring areas have yet to be described in the mouse brain, limiting our understanding of
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10.09.2025

Functional synapses between neurons and small cell lung cancer

Authors Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Ianicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM,
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09.09.2025

Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of postoperative atrial fibrillation

Authors Fakuade FE, Gronwald J, Brandes P, Döring Y, Rubio T, Seibertz F, Knierim M, Abu-Taha IH, El-Essawi A, Jebran AF, Danner BC, Baraki H, Kamler M, Kutschka I, Heijman J, Dobrev D, Schmidt C, Kallenberger SM, Voigt N Journal European Heart Journal Citation Eur Heart J. 2025 Sep 9:ehaf609.
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08.09.2025

Interpreting convolutional neural networks to study wide-field amacrine cell inhibition in the retina

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2025.09.08.674839. Abstract Wide-field amacrine cells (ACs) play a unique role in retinal processing by integrating visual information across a large spatial area. Their inhibitory influence has been implicated in multiple retinal functions such as differential
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08.09.2025

Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry

Authors Vona B, Wollnik B, Strenzke N, Pangrsic T, Moser T Journal MedComm Citation MedComm 6, no. 9 (2025): 6, e70363. Abstract CABP2 modulates presynaptic CaV1.3 Ca2+ channel function in inner hair cells (IHCs) and is required for indefatigable synaptic sound encoding. Biallelic variants in CABP2 are associated with non-syndromic
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06.09.2025

Sharp Convergence Rates of Empirical Unbalanced Optimal Transport for Spatio-Temporal Point Processes

Authors Struleva M, Hundrieser S, Schuhmacher D, Munk A Journal Arxiv Citation arXiv:2509.04225. Abstract We statistically analyze empirical plug-in estimators for unbalanced optimal transport (UOT) formalisms, focusing on the Kantorovich-Rubinstein distance, between general intensity measures based on observations from spatio-temporal point processes. Specifically, we model the observations by two weakly
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