2025

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Prof. Nadja Simeth-Crespi, MBExC member and leader of the Molecular Labeling Chemistry group at the Institute for Organic and Biomolecular Chemistry, University of Göttingen. Photo: MBExC / Swen Pförtner.

03.04.2025

Nadja Simeth-Crespi appointed as W2 professor of Molecular Labeling Chemistry

Congratulations to MBExC member Nadja Simeth-Crespi on her appointment as W2 Professor of Molecular Labeling Chemistry at the University of Göttingen!   Prof. Simeth-Crespi and her team’s research intersects the boundaries of bioorganic and photochemistry, with a focus on the design of smart drugs, biochemical probes and labels, as well
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02.04.2025

Power-law adaptation in the presynaptic vesicle cycle

Authors Mikulasch FA, Georgiev SV, Rudelt L, Rizzoli SO, Priesemann V Journal Communications Biology Citation Commun Biol. 2025 Apr 2;8(1):542. Abstract After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and
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31.03.2025

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Authors Zipf D, Vogt M, Sathyanarayanan U, Wagdi A, Riebeling J, Patejdl R, Bruegmann T Journal Neurogastroenterology and Motility Citation Neurogastroenterol Motil. 2025 Mar 31:e70028. Abstract Background: Optogenetics is a cutting-edge approach that can enable direct stimulation of gastric smooth muscle cells (SMC) by combining cell-specific overexpression of light-sensitive proteins
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Living neurons receive signals from different sources, process them and pass an output signal on to other neurons (left). In the artificial neuron model, this information processing can be described and improved by a learning objective (right). Similar to their biological models, this independent learning allows novel artificial neurons to solve tasks in a self-organized way. Photo: Andreas Schneider

28.03.2025

Artificial neurons organize themselves

Göttingen research team constructs network of self-learning infomorphic neurons   Novel artificial neurons learn independently and are more strongly modeled on their biological counterparts. A team of researchers from the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN) at the University of Göttingen and the Max Planck Institute for
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27.03.2025

Understanding mitochondrial protein import: a revised model of the presequence translocase

Authors Jain N, Chacinska A, Rehling P Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2025 Mar 27:S0968-0004(25)00050-7. Abstract Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial
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26.03.2025

The inner nuclear layer in pediatric multiple sclerosis

Authors Hummel-Abmeier H, Naxer S, Kadas EM, Zimmermann H, Knaack B, Huppke P, Kowallick A, Meier K, Brandt AU, Paul F, Schittkowski M, Oertel FC, Gärtner J Journal Neurology: Neuroimmunology and Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2025 May;12(3):e200387. Abstract Background and objectives: Pediatric onset multiple sclerosis (POMS) leads to optic
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26.03.2025

Microtubules as a versatile reference standard for expansion microscopy

Authors Chowdhury R, Mimoso T, Chouaib AA, Mougios N, Krah D, Opazo F, Köster S, Rizzoli SO, Shaib AH Journal Communications Biology Citation Commun Biol. 2025 Mar 26;8(1):499. Abstract Expansion microscopy (ExM) is continually improving, and new ExM variants need to be validated on well-defined biological structures. There is no
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Dr. Thomas Frank, MBExC member and leader of the Zebrafish Neurobiology group at the European Neuroscience Institute. Photo: private.

25.03.2025

Thomas Frank receives project funding from the Schram Foundation

MBExC member Dr. Thomas Frank has received €360,000 in project funding over three years from the Schram Foundation. His project “Cellular mechanisms and brain-wide circuits of chemosensory valence coding” uses zebrafish as a model organism to investigate how the brain processes sensory information, such as odors, across different levels of
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Prof. Dr. Urs Valentin Nägerl, Director of the Institute of Anatomy and Cell Biology at the University Medical Center Göttingen (UMG). Photo: umg/swen pförtner

25.03.2025

Public inaugural lecture by Prof. Dr. Urs Valentin Nägerl

Shadows and glimpses of light: structure and function of the interstitial space in the brain   MBExC member Prof. Dr. Urs Valentin Nägerl has held the University Professorship of Anatomy and Cell Biology at the University Medical Center Göttingen (UMG) since September 1, 2024 and heads the Institute of Anatomy
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25.03.2025

Tiling artifacts and trade-offs of feature normalization in the segmentation of large biological images

Authors Buglakova E, Archit A, D’Imprima E, Mahamid J, Pape C, Kreshuk A Journal Arxiv Citation arXiv:2503.19545. Abstract Segmentation of very large images is a common problem in microscopy, medical imaging or remote sensing. The problem is usually addressed by sliding window inference, which can theoretically lead to seamlessly stitched
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