2025

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Dr. Thomas Frank, MBExC member and leader of the Zebrafish Neurobiology group at the European Neuroscience Institute. Photo: private.

25.03.2025

Thomas Frank receives project funding from the Schram Foundation

MBExC member Dr. Thomas Frank has received €360,000 in project funding over three years from the Schram Foundation. His project “Cellular mechanisms and brain-wide circuits of chemosensory valence coding” uses zebrafish as a model organism to investigate how the brain processes sensory information, such as odors, across different levels of
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Prof. Dr. Urs Valentin Nägerl, Director of the Institute of Anatomy and Cell Biology at the University Medical Center Göttingen (UMG). Photo: umg/swen pförtner

25.03.2025

Public inaugural lecture by Prof. Dr. Urs Valentin Nägerl

Shadows and glimpses of light: structure and function of the interstitial space in the brain   MBExC member Prof. Dr. Urs Valentin Nägerl has held the University Professorship of Anatomy and Cell Biology at the University Medical Center Göttingen (UMG) since September 1, 2024 and heads the Institute of Anatomy
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25.03.2025

Tiling artifacts and trade-offs of feature normalization in the segmentation of large biological images

Authors Buglakova E, Archit A, D’Imprima E, Mahamid J, Pape C, Kreshuk A Journal Arxiv Citation arXiv:2503.19545. Abstract Segmentation of very large images is a common problem in microscopy, medical imaging or remote sensing. The problem is usually addressed by sliding window inference, which can theoretically lead to seamlessly stitched
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Dr. Shayan Hundrieser at the award ceremony with the spokesperson of the German Mathematical Society Stochastics Division, Prof. Dr. Claudia Kirch. Photo: private

Dr. Shayan Hundrieser at the award ceremony with the spokesperson of the German Mathematical Society Stochastics Division, Prof. Dr. Claudia Kirch. Photo: private

24.03.2025

Shayan Hundrieser received Dissertation Award

Dr. Shayan Hundrieser, mathematician from the University of Göttingen has been honored with the prestigious Dissertation Award by the Probability and Statistics Group of the German Mathematical Society. The award acknowledges outstanding research by promising young scientists in the field of stochastics. His dissertation, entitled “Statistical Optimal Transport and its
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24.03.2025

XRCC4-related microcephalic primordial dwarfism: description of a clinical series of 7 cases, phenotype expansion and new diagnostic approaches

Authors Cuinat S, Chatron N, Petit F, Brunelle P, Dincuff E, Aubert Mucca M, Bieth E, Schmetz A, Rieder H, Wollnik B, Kaulfuß S, Yigit G, McKeown C, Savage T, Mulligan MR, Bicknell LS, Corsten-Janssen N, Edery P, Lesca G, de Villartay JP, Putoux A Journal European Journal of Human
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24.03.2025

PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis

Authors Georgiev SV, Rizzoli SO Journal Scientific Reports Citation Sci Rep 15, 10093 (2025). Abstract Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of the synaptic vesicle, have
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Heart & Brain exhibition at Göttingen Science Museum Forum Wissen Göttingen
23.03.2025

360° Tour of MBExC Heart & Brain exhibition at Göttingen Science Museum Forum Wissen

    Welcome to the exhibition ‘Heart & Brain – Understanding Together’! On this virtual tour, we invite you to join us on a journey through the past special exhibition of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC), which took place in the Göttingen Forum Wissen in 2024. With
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22.03.2025

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity

Authors Lin KH, Ranjan M, Lipstein N, Brose N, Neher E, Taschenberger H Journal The Journal of Physiology Citation J Physiol. 2025 Mar 22. Abstract Heterogeneity in synaptic strength and short-term plasticity (STP) was characterized in post-hearing rat calyx of Held synapses at near-physiological external [Ca2+] under control conditions and
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21.03.2025

In situ architecture of the human prohibitin complex

Authors Lange F, Ratz M, Dohrke JN, Wenzel D, Ilgen P, Riedel D, Jakobs S Journal Nature Cell Biology Citation Nat Cell Biol (2025). Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle
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18.03.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025; 15(10):4270-4286. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept
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