2025

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08.09.2025

Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry

Authors Vona B, Wollnik B, Strenzke N, Pangrsic T, Moser T Journal MedComm Citation MedComm 6, no. 9 (2025): 6, e70363. Abstract CABP2 modulates presynaptic CaV1.3 Ca2+ channel function in inner hair cells (IHCs) and is required for indefatigable synaptic sound encoding. Biallelic variants in CABP2 are associated with non-syndromic
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06.09.2025

Sharp Convergence Rates of Empirical Unbalanced Optimal Transport for Spatio-Temporal Point Processes

Authors Struleva M, Hundrieser S, Schuhmacher D, Munk A Journal Arxiv Citation arXiv:2509.04225. Abstract We statistically analyze empirical plug-in estimators for unbalanced optimal transport (UOT) formalisms, focusing on the Kantorovich-Rubinstein distance, between general intensity measures based on observations from spatio-temporal point processes. Specifically, we model the observations by two weakly
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06.09.2025

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Authors Holthusen H, Trinkaus VA, Fernandez Gonzalez C, Saha I, Pachmayr I, Wade OK, Dieser A, Hummel B, Yuste-Checa P, Ehses K, Körner R, Fernández-Busnadiego R, Sawarkar R, Jungmann R, Hipp MS, Hartl FU Journal BioRxiv Citation bioRxiv 2025.09.05.673478. Abstract Protein aggregation in various cellular compartments is a hallmark of
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05.09.2025

Uncoupling of CSF biomarkers and clinical status in patients with a novel mutation of ATP13a2

Authors Stephani C, Ewers D, Stausberg D, Rasche D, Bahiraee A, Ahmad B, Baehr M, Downie B, Hirschel S, Pauli SJ, Riedel C, Sachkova A, Salinas G, Schneider A, van Riesen C, Wollnik B, Yigit G, Nave K, Zerr I, Eggert S, Sereda MW Journal MedRxiv Citation medRxiv 2025.09.02.25334661. Abstract
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04.09.2025

A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson’s Disease

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Busnadiego RF, Mollenhauer B,
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Dr. Oliver Barnstedt, junior research group leader for “Multiscale Circuit Analysis” at the European Neuroscience Institute (ENI), University Medical Center Göttingen. Photo: Robin Ritter.

04.09.2025

Oliver Barnstedt receives ERC Starting Grant

MBExC member and Neuroscientist Dr. Oliver Barnstedt from the European Neuroscience Institute Göttingen (ENI-G) receives an ERC Starting Grant for his project “LearnMamBo: Neuronal dynamics of learning and memory in the mammillary body“. This projects will run for five years with a budget of around 1.5 million euros.   You
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Dr. Oliver Barnstedt, junior research group leader for “Multiscale Circuit Analysis” at the European Neuroscience Institute (ENI), University Medical Center Göttingen. Photo: Robin Ritter.

04.09.2025

International awards for researchers at the Göttingen Campus

Dr. Oliver Barnstedt and Dr. Anggi Hapsari each receive an ERC Starting Grant   Two researchers at the Göttingen Campus have been awarded ERC Starting Grants by the European Research Council (ERC). MBExC member and Neuroscientist Dr. Oliver Barnstedt from the European Neuroscience Institute Göttingen (ENI-G) receives funding for his
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03.09.2025

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Authors Siems SB, Jung RB, Jahn O, Meschkat M, Michanski S, Lukasik N, Hummert S, Sasmita AO, Mobius W, Benseler F, Brose N, Kramer-Albers EM, Haucke V, Nave KA, Werner HB Journal BioRxiv Citation bioRxiv 2025.09.02.673641. Abstract Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing
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02.09.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Kibédi CZ, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Science Advances Citation Science Advances, 2025. accepted manuscript. Abstract Our
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28.08.2025

Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins

Authors Pikunov AV, Syunyaev RA, Ali R, Prakosa A, Gams A, Boyle PM, Steckmeister V, Kutschka I, Rytkin E, Voigt N, Trayanova N, Efimov IR Journal Circulation: Arrhythmia and Electrophysiology Citation Circ Arrhythm Electrophysiol. 2025 Aug 28:e013898. Abstract Background: Atrial fibrillation (AF) is a progressive disease involving both structural and
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