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17.12.2025

Self-blinking dye restores efficient use of nanobodies in single-molecule localization microscopy

Authors Basak S, Inamdar K, Pollack YG, Albert L, Jans DC, Jakobs S, Enderlein J, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2025.12.17.694880 Abstract Direct STORM relies on robust fluorophore blinking; observations suggest that AlexaFluor647 underperforms when coupled to nanobodies, thereby undermining the advantages of nanobodies. We show that
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17.12.2025

MedicoSAM: Robust Improvement of SAM for Medical Imaging

Authors Archit A, Freckmann L, Pape C Journal IEEE Transactions on Medical Imaging Citation IEEE Trans Med Imaging. 2025 Dec 17;PP. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models
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16.12.2025

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism for direct substrates transfer

Authors Maestro-Lopez M, Cheng TC, Muntaner J, Menendez M, Alonso M, Schweitzer A, Ishizaka M, Tomko Jr. RJ, Cuellar J, Valpuesta JM, Sakata E Journal Science Advances Citation Sci Adv. (2025). accepted manuscript. Abstract The 26S proteasome primarily degrades proteins marked by polyubiquitin chains. Although ubiquitin-independent pathways for proteasomal degradation
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Computer-generated image of a human placenta, measured using virtual 3D histology. Any cross-sectional images can be superimposed on the organ virtually in high resolution. This allows the length scales of anatomy and histology to be linked and the entire organ to be examined for abnormalities in tissue architecture, for example. Photo: J. Reichmann et al., PNAS Nexus 2025.

16.12.2025

Tim Salditt receives innovation award from Helmholtz Center

The Helmholtz Center in Berlin has awarded its Innovation Award to three scientists for their pioneering work in the field of histological tomography: physicist and MBExC member Prof. Dr. Tim Salditt from the University of Göttingen, pathologist Prof. Dr. Danny Jonigk from RWTH University Hospital Aachen, and pathologist and anatomist
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15.12.2025

Transforming Atrial Fibrillation Management by Targeting Comorbidities and Reducing Atrial Fibrillation Burden: the 10th AFNET/EHRA Consensus Conference

Authors Svennberg E, Merino JL, Andrade J, Anselmino M, Arbelo E, Boersma E, Boriani G, Breithardt G, Chung M, Chyou J, Cohen A, Nielsen JC, Dichtl W, Diederichsen SZ, Dobrev D, Doehner W, Dworatzek E, Fabritz L, Filgueiras-Rama D, Gimpelewitz C, Hack G, Hatem S, Healey J, Heidbuchel H, Hijazi
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A new epidemiological model shows a paradoxical result: increased infection rates for sexually transmitted diseases may be due to increased testing, while the actual prevalence is declining. © MPI-DS

15.12.2025

A testing paradox for sexually transmitted infections

For several years, pre-exposure prophylaxis against HIV (PrEP) has been a major success in preventing new cases. However, individuals on PrEP typically engage in riskier sexual behavior and thus are more susceptible to acquiring other sexually transmitted infections (STIs). To counteract this, people on PrEP have to regularly take mandatory
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12.12.2025

Optimizing infectious disease mitigation under dynamic conditions

Authors Müller L, Sartori F, Dehning J, Eggl MF, Priesemann V Journal Arxiv Citation arXiv:2512.11454. Abstract Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but they impose considerable societal, individual, and economic costs. We developed a general optimization framework to balance costs related
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10.12.2025

Distributional limits of graph cuts on discretized grids

Authors Suchan L, Li H, Munk A Journal Electronic Journal of Statistics Citation Electron. J. Statist. 19(2): 5925-5978 (2025). Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a
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10.12.2025

Research highlight: new and powerful approach to wide-field fluorescence lifetime imaging with single-molecule sensitivity

Authors Enderlein J Journal eLight Citation eLight 5, 34 (2025). Abstract Historically constrained by the low throughput of traditional Time-Correlated Single-Photon Counting (TCSPC), a new method utilizes an optimized, time-gated single-photon camera acquisition scheme for achieving single-molecule lifetime precision comparable to TCSPC, but across a wide field of view simultaneously.
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09.12.2025

Fast scanning small angle X-ray scattering of hydrated biological cells

Authors Yu B, Sinha M, Mendes Da Silva R, Roelleke U, Burghammer M, Koester S Journal BioRxiv Citation bioRxiv 2025.12.05.692524. Abstract Due to their high penetration depth, X-rays enable us to obtain information from the interior of whole, unsliced cells. Scanning small angle X-ray scattering (SAXS), in particular, reveals real-space
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